|
|
|
| Efficacy of Intralesional Injection Combined with Surgical Excision and Laser Therapy in the Treatment of Facial Hyperplastic Scarring and the Influence on VSS Score and Pruritus Score |
| ZHAO Qian, MA Ying |
| The First Affiliated Hospital of Air Force Military Medical University, Shaanxi Xi'an 710032, China |
|
|
|
|
Abstract Objective: To study the effect of intralesional injection combined with surgical excision and laser therapy for treating facial hyperplastic scarring on the Vancouver Scar Scale (VSS) score and pruritus score. Methods: From January 2019 to January 2021, 153 patients with facial hyperplastic scar were treated in the Department of Plastic Surgery, Xijing Hospital. The patients were randomly divided into groups A, B, and C by random number table method, with 51 cases in each group, treated with surgical excision, intralesional injection combined with surgical excision, and intralesional injection combined with surgical excision and laser therapy, respectively. Clinical effects, VSS scores, pruritus and pain scores, and adverse reactions were compared among the groups. Results: There were statistically significant differences in total effective rate among the 3 groups (H=22.236, P≤0.001, χ2=9.590, P=0.008). The clinical recovery rate and total effective rate in group C were significantly higher than those in group A and group B (P<0.05), but there was no statistically significant difference between group A and group B (P>0.05). The scores for scar thickness, color, blood vessel distribution, and flexibility, and the total scores in the 3 groups were similar before treatment (P>0.05). After treatment, the above scores in the 3 groups decreased, and group C had significantly lower scores than group A and group B (P<0.05). The difference values of these scores at T1 and T2 were significantly higher in group C than in group A and group B (P<0.05). The 3 groups had similar NRS scores and VAS scores before treatment (P>0.05). After treatment, the NRS scores and VAS scores in the 3 groups decreased significantly, and group C had significantly lower scores than group A and group B (P<0.05). The difference values of NRS scores and VAS scores at T1 and T2 were significantly higher in group C than in group A and group B (P<0.05). Adverse reactions were observed in all groups but were tolerable. The total incidence of adverse reactions in group C was significantly lower than that in group A or group B (P<0.05). Conclusion: Intralesional injection combined with surgical excision and laser therapy is effective in the treatment of facial hyperplastic scars, and can significantly reduce the VSS score and pruritus score.
|
|
|
|
|
|
[1] 黄振,郑大伟,张旭阳,等.小颗粒脂肪注射在面部增生性瘢痕治疗中的应用[J].中华整形外科杂志,2019,35(4):381-385.
[2] 李大鹏.美容缝合联合剥脱性二氧化碳点阵激光治疗颌面部增生性瘢痕的效果观察[J].中国美容医学,2020,29(8):85-87.
[3] 蔡景龙.现代瘢痕学[M].北京:人民卫生出版社,2008.104-105.
[4] 刘海兵,唐丹,曹海燕,等.温哥华瘢痕量表的信度研究[J].中国康复医学杂志,2006,21(3):240-242.
[5] 李昂,李雪阳,杨帅,等.2940nm铒点阵激光联合595nm脉冲染料激光结合水光注射仪导入曲安奈德治疗增生性瘢痕效果观察[J].徐州医科大学学报,2021,41(3):219-222.
[6] 高万露,汪小海.患者疼痛评分法的术前选择及术后疼痛评估的效果分析[J].实用医学杂志,2013,29(23):3892-3894.
[7] 左楠,王远,王爽.骨髓间充质干细胞移植联合多点微量注射曲安奈德对兔耳增生性瘢痕及创面巨噬细胞极化的影响[J].陕西医学杂志,2022,51(2):140-144.
[8] 沈小鹏,李东.瘢痕防治及其研究进展[J].中华临床医师杂志(电子版),2019,13(6):463-467.
[9] 张小刚,马驰蛟,邬天刚,等.点阵激光联合复方倍他米松注射液对增生性瘢痕患者血清TGF-β1、BMP-7、EGF水平变化及预后的影响[J].医学临床研究,2018,35(1):33-36.
[10] 江兰,张衍国,王小霞,等.CO2点阵激光联合注射醋酸泼尼松龙治疗增生性瘢痕临床观察[J].海南医学,2020,31(14):1829-1832. |
|
|
|
2023, Vol. 29 
