sLOX-1 HIF-1α IGF-1对动脉瘤性蛛网膜下腔出血后迟发性脑缺血的预测价值研究

doi:10.3969/j.issn.1006-6233.2023.02.019

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Abstract Objective: To explore the predictive value of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1), hypoxia-inducible factor-1α (HIF-1α), and insulin-like growth factor-1 (IGF-1) on delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). Methods: A total of 104 patients with aSAH in the hospital from March 2019 to March 2022 were selected as the research subjects. According to the occurrence of DCI, the patients were divided into a DCI group and a non-DCI group. The general clinical data [triacylglycerol (TG), intracranial pressure (ICP), Hunt-Hess grading] and serum sLOX-1, HIF-1α, and IGF-1 levels were compared between the two groups. Pearson correlation analysis was used to analyze the correlation between serum sLOX-1, HIF-1α, IGF-1 and TG, ICP, and Hunt-Hess grading. The receiver operating characteristic (ROC) curve was drawn to assess the predictive efficiency of serum sLOX-1, HIF-1α, and IGF-1 on DCI after aSAH. Results: The TG, ICP and Hunt-Hess grading in the DCI group were higher than those in the non-DCI group (P<0.05). The levels of serum sLOX-1 and HIF-1α in the DCI group were higher than those in the non-DCI group (P<0.05) while the level of IGF-1 was lower than that in the non-DIC group (P<0.05). Pearson correlation analysis showed that serum sLOX-1 and HIF-1α levels were positively correlated with TG, ICP, and Hunt-Hess grading (P<0.05), but serum IGF-1 level was negatively correlated with TG, ICP, and Hunt-Hess grading (P<0.05). ROC curve showed that the sensitivities and specificities of serum sLOX-1, HIF-1α, IGF-1 alone and in combination on predicting DCI after aSAH were 87.10%/79.50%, 90.30%/83.60%, 83.90%/79.50%, and 96.80%/78.10% respectively, and the corresponding AUCs were 0.894, 0.920, 0.886, and 0.975 respectively. Conclusion: sLOX-1, HIF-1α, and IGF-1 are related to the occurrence of DCI after aSAH, and combined detection can predict DCI after aSAH to a certain extent.

Key words： Aneurysmal subarachnoid hemorrhage Delayed cerebral ischemia Soluble lectin-like oxidized low-density lipoprotein receptor-1 Hypoxia-inducible factor-1α Insulin-like growth factor-1 Predictive value

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	JIANG Haiyang
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JIANG Haiyang,CHEN Hu,et al. Predictive Value of sLOX-1, HIF-1α and IGF-1 on Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage[J]. HeBei Med, 2023, 29(2): 280-284.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.02.019 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I2/280

[1] 齐丽霞,李自如,姚远,等.定量脑电图联合经颅多普勒超声对动脉瘤蛛网膜下腔出血后迟发性脑缺血的预测价值研究[J].实用心脑肺血管病杂志,2022,30(4):99-103.
[2] 段婉莹,刘丽萍,杨中华,等.动脉瘤性蛛网膜下腔出血后迟发性脑缺血的早期凝血及纤溶生物标志物变化[J].中国脑血管病杂志,2020,17(1):17-25.
[3] 王娜,卞玉杰,田继新.血清mir-210、HIF-1α水平与动脉瘤性蛛网膜下腔出血后迟发性脑缺血的关系[J].中风与神经疾病杂志,2020,37(4):302-305.
[4] 陈素云,赵志新,杨仙鸿,等.NLR和AFR与动脉瘤性蛛网膜下腔出血患者迟发性脑缺血的关系研究[J].浙江医学,2020,42(14):1485-1488.
[5] 曲鑫,李任伟,欧斯奇,等.动脉血乳酸水平在动脉瘤性蛛网膜下腔出血中的临床意义[J].中华神经外科杂志,2020,36(8):785-790.
[6] 巫颖,龚细礼.早期侧脑室引流及动脉瘤栓塞术对Hunt-hessⅢ级原发性蛛网膜下腔出血的疗效分析[J].湖南师范大学学报(医学版),2020,17(1):29-33.
[7] 范存刚,孙澎,张庆俊.2012年AHA/ASA《动脉瘤性蛛网膜下腔出血的诊疗指南》解读[J].中华神经医学杂志,2013,12(6):541-544.
[8] Zafara SF,Westover MB,Gaspard N,et al.Interrater agreement for consensus definitions of delayed ischemic events after aneurysmal subarachnoid hemorrage [J].Clin Neurophysiol,2016,33(3):235-240
[9] 郭百海,周丽,彭德强.破裂的颅内动脉瘤大小联合Hunt-Hess分级对治疗和预后的评价[J].中国医师进修杂志,2012,14(11):41-43.
[10] 刘昊楠,李爱民.动脉瘤性蛛网膜下腔出血后迟发性脑缺血发生机制的研究进展[J].安徽医药,2020,24(12):2333-2336.
[11] 李宏建.Isofuran和异前列腺素作为动脉瘤性蛛网膜下腔出血后迟发性脑缺血的潜在标志物[J].国际脑血管病杂志,2021,29(11):872-872.
[12] 汤华,陈少军,韩晶,等.1-磷酸鞘胺醇与动脉瘤性蛛网膜下腔出血后脑血管痉挛的相关性研究[J].神经损伤与功能重建,2021,16(11):656-659.
[13] 张振,张恒柱,李育平,等.全身炎症反应指数与动脉瘤性蛛网膜下腔出血术后症状性脑血管痉挛的关系及Nomogram预测模型的建立[J].实用临床医药杂志,2020,24(10):36-40.
[14] Os H,Ruigrok Y M,Verbaan D,et al.Delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage in patients with a history of migraine[J].Stroke,2020,51(10):2807-2811.