精索静脉结扎术对精索静脉曲张患者精子总抗氧化能力的影响

doi:10.3969/j.issn.1006-6233.2022.11.029

Abstract
Figure/Table
References
Related Citation (1)

Download: PDF (1198 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To evaluate the effect of spermatic vein ligation on the total antioxidant capacity (TAC) of semen in patients with varicocele.Methods: Forty infertile male patients with varicocele and 40 healthy controls (control group) were admitted to our hospital for primary or secondary infertility. Patients with varicocele were divided into two groups: nonobvious palpation (GI) varicocele group (16 cases) and obvious palpation (GⅡ-Ⅲ) varicocele group (24 topics). All patients underwent microscopical ligation of the spermatic vein. The semen TAC level and sperm parameters of all patients were evaluated. The preoperative sperm quantity, sperm motility, sperm morphology, and semen TAC level were compared with the same parameters 3 ~ 6 months after spermatic vein ligation and the control group. Results: After spermatic vein ligation, the sperm count (preoperative 18.01±1.88, postoperative 24.20±7.60, P=0.040), motile sperm (preoperative 17.90±8.90, postoperative 23.90±7.90, P=0.001), NF (10.20±3.02 before operation, 19.30±7.05 after operation, P<0.001) and semen TAC level (2.52±0.28 before operation, 3.72±0.20 after operation, P=0.031) were higher than those before operation, and the difference was statistically significant (P<0.05); and compared with the control group after operation, sperm count (varicocele patients 24.20±7.60, control group 29.40±8.30, P=0.156), sperm motility (varicocele patients 23.90±7.90, control group 23.90±7.90) 30.50±8.00, P=0.465), NF (varicocele patients 19.30±7.05, control group 23.90±7.90, P=0.085) and semen TAC level (varicocele patients 3.72±0.20, control group 2.78±0.20, P=0.666), the difference was not statistically significant (P>0.05). However, according to the evaluation of the patients' varicocele grade, only patients with GII-III varicocele had NF before and after surgery (6.16±2.50 preoperatively, 10.00±6.41 postoperatively, P=0.040), TAC (preoperatively 6.16±2.50, P=0.040). 2.36±0.23, postoperative 2.66±0.15, P=0.040) level difference was statistically significant (P<0.05). When the patients were grouped according to semen parameters, there was a statistically significant difference in TAC levels in the oligospermia (OAT) group (2.46 ± 0.34 before surgery, 2.80 ± 0.19 after surgery, P=0.000). Conclusion: Spermatic vein ligation significantly improves the total antioxidant capacity of semen in patients with GII-III varicocele.

Key words： Male infertility Total antioxidant capacity Varicocele Sperm

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Junjie
	YANG Yang
	LUO Xuan
	et al

Cite this article:

ZHANG Junjie,YANG Yang,LUO Xuan, et al. Effect of Spermatic Vein Ligation on Total Antioxidant Capacity of Sperms in Patients with Varicocele[J]. HeBei Med, 2022, 28(11): 1902-1905.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.11.029 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I11/1902

[1] 刘毅东,王鸿祥.精索静脉曲张手术治疗安全共识[J].现代泌尿外科杂志,2019,24(6):13-17.
[2] 刘红军,梁新安,李秀宁,等.生精汤联合腹腔镜下精索静脉高位结扎术在精索静脉曲张性不育症中的应用价值研究[J].中国计划生育和妇产科,2020,12(10):69-73.
[3] 于明杰,易虎,金珊,等.精索静脉曲张患者行高位结扎术后对ASA水平及精子质量影响[J].重庆医学,2020,49(9):1446-1449,1454
[4] 陈舜,薛恩生,梁荣喜,等.超声分级结合血清生殖激素评估精索静脉曲张患者生育力[J].中国医学影像技术,2020,36(2):261-265.
[5] 华斌,王书斌,陈妍妍.精索静脉曲张患者精浆TGF-β,IL-2及IL-6水平与精液质量的关系研究[J].现代检验医学杂志,2020,35(4):56-58,66.
[6] Cavallini G,Scroppo F I,Colpi G M.The clinical usefulness of a novel grading system for varicocoeles using duplex doppler ultrasound examination based on postsurgical modifications of seminal parameters[J].Andrology,2019,7(1):62-68.
[7] 袁海川,宋武,顾朝辉,等.精索静脉曲张显微手术后抗精子抗体水平与精子质量相关性分析[J].中国临床医学,2019,26(6):885-888.
[8] 刘洪志,彭华,李硕丰.不同手术方式治疗精索静脉曲张的疗效比较[J].国际外科学杂志,2020,47(1):35-40.
[9] Tak O K,Woon K S,Ku K S,et al.An analysis of major causes of surgical failure using bhren system in intraoperative venography during varicocelectomy[J].Yonsei medical journal,2021,62(10):928-935.
[10] Yousefnia-Pasha Y,Mahjoub S,Gholami M,et al.Comparison of oxidative stress intensity in the seminal plasma and serum of infertile patients with different varicocele grades and subjects with no varicocele: a cross-sectional study[J].Iranian Red Crescent Medical Journal,2018,20(6):112-118.
[11] Hassani-Bafrani H,Najaran H,Razi M,et al.Berberine ameliorates experimental varicocele-induced damages at testis and sperm levels; evidences for oxidative stress and inflammation[J].Andrologia,2019,51(2):131-143.
[12] Gnessi L,Scarselli F,Minasi M G,et al.Testicular histopathology,semen analysis and FSH,predictive value of sperm retrieval: supportive counseling in case of reoperation after testicular sperm extraction (TESE)[J].BMC urology,2018,18(1):1-8.
[13] Machen G L,Johnson D,Nissen M A,et al.Time to improvement of semen parameters after microscopic varicocelectomy: when it occurs and its effects on fertility[J].Andrologia,2020,52(2): 135-143.
[14] Kizilay F,Altay B.Evaluation of the effects of antioxidant treatment on sperm parameters and pregnancy rates in infertile patients after varicocelectomy: a randomized controlled trial[J].International journal of impotence research,2019,31(6):424-431.
[15] Machen G L,Johnson D,Nissen M A,et al.Time to improvement of semen parameters after microscopic varicocelectomy: when it occurs and its effects on fertility[J].Andrologia,2020,52(2): 135-143.