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| The Expression Levels of STIL and PRR11 in Cervical Cancer Tissues and Their Correlation with Lymph Node Tissue Metastasis |
| GAN Lu, et al |
| Jingzhou Hospital Affiliated to Yangtze University / Jingzhou Central Hospital, Hubei Jingzhou 434020, China |
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Abstract Objective: To analyze the expression levels of SCL/TALl interrupting locus (STIL) and proline-rich protein 11 (PRR11) in cervical cancer tissues and their correlation with lymph node metastasis. Methods: A total of 143 patients with cervical cancer admitted to the hospital were enrolled as the research subjects between January 2020 and January 2022. During surgery, cervical cancer tissues and adjacent normal para-carcinoma tissues were collected. The levels of STIL and PRR11 in cancer tissues and para-carcinoma tissues were detected by Western Blot. The mRNA levels of STIL and PRR11 were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The levels of STIL and PRR11 in patients with different FIGO staging, and between patients with or without lymph node metastasis were compared. The diagnostic value of STIL and PRR11 for lymph node metastasis was analyzed by receiver operating characteristic (ROC) curves, which were represented by the area under the curve (AUC). The correlation between STIL and PRR11 was analyzed by the Pearson method. Results: The levels of STIL and PRR11, and relative expression levels of their genes in cervical cancer tissues were significantly higher than those in para-carcinoma tissues (P<0.05). The higher the FIGO staging, the higher the levels of STIL and PRR11 (P<0.05). The levels of STIL and PRR11 in patients with lymph node metastasis were significantly higher than those without metastasis (P<0.05). AUC values of STIL and PRR11 in the diagnosis of lymph node metastasis were 0.733 and 0.729, respectively (P<0.05). Pearson correlation analysis showed that there was a significant correlation between STIL and PRR11 in cancer tissues (P<0.05). Conclusion: The expressions of STIL and PRR11 are up-regulated in cervical cancer tissues. And their increase indicates the increased risk of lymph node metastasis. STIL and PRR11 can assess lymph node metastasis in cervical cancer.
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2022, Vol. 28 
