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Effectiveness of Extract of Ginkgo Biloba Leaves Injection Combined with Doperidonezide in the Treatment of Vascular Dementia in the Elderly and Its Effect on Cognitive Function and Oxidative Stress Response |
PENG Fei, WANG Ruiping, ZHANG Wei, et al |
Jinqiu Hospital, Liaoning Shenyang 110000, China |
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Abstract Objective: To explore the effect of extract of ginkgo biloba leaves injection combined with donepezil on senile vascular dementia and its influence on cognitive function and oxidative stress. Methods: The data of 90 aged patients who had vascular dementia treatment in our hospital from May 2019 to December 2021 were retrospectively analyzed. All patients were divided into two groups, the observation group (n=45) and the control group (n=45), according to different treatment methods. People in the control group were administered donepezil hydrochloride tablets, while the people in the observation group were administered extract of ginkgo biloba leaves injection combined with donepezil hydrochloride tablets. All patients were treated continuously for 2 months. The therapeutic effect, cognitive function, self-care ability, and indexes related to oxidative stress were compared before and after treatment. Results: The total effective rate of treatment in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the scores on the MMES scale and Barthel index in the two groups were significantly higher than those before treatment. After treatment, the contents of serum homocysteine (Hcy), interferon-γ (IFN-γ), and malondialdehyde (MDA) in both groups were significantly lower than those before treatment, while the contents of superoxide dismutase (SOD) in both groups were significantly higher than those before treatment. Conclusion: Extract of ginkgo biloba leaves injection combined with doxepinezi can improve the cognitive function of elderly patients with vascular dementia, improve self-care ability, and reduce the content of oxidative stress reaction index. The therapeutic effect is remarkable, and it is worthy of clinical application.
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