|
|
|
| Effects of Caffeine Citrate Combined with Mild Hypothermia on the Levels of S100B and MMP-9 in Premature Infants with Brain Injury |
| JI Juhua, HONG Fei, SONG Lei |
| Nantong First People's Hospital / The Second Affiliated Hospital of Nantong University, Jiangsu Nantong 226000, China |
|
|
|
|
Abstract Objective: To observe the effect of caffeine citrate combined with mild hypothermia on the levels of S100B and MMP-9 in premature infants with brain injury. Methods: A total of 60 premature infants with brain injury who were treated in the hospital from May 2018 to May 2021 were selected and randomly divided into 2 groups. 30 children in the control group were given basic treatment and caffeine citrate and 30 children in the experimental group were given basic treatment, caffeine citrate combined with sublimation. The levels of S100B, matrix metalloproteinase-9 (MMP-9), neurofilament protein H phosphorylated isoform (pNF-H), glial fibrillary acidic protein (GFAP), tumor necrosis factor-α (TNF-α), Toll-like receptor-4 (TLR-4), interleukin-1β (IL-1β), superoxide dismutase (SOD), lipid peroxide (P-LPO) and reactive oxygen species (ROS) were measured before and after treatment. The levels of lipid peroxide (P-LPO) and reactive oxygen species (ROS) were recorded, and the time to recovery of primitive reflexes, time to recovery of muscle tone, time to recovery of consciousness, time to voluntary suckling, and days of hospitalization were recorded in both groups. Results: The level of TNF-α, TLR-4, and IL-1β were lower in the experimental group than in the control group (P<0.05), the level of SOD was higher in the experimental group than in the control group (P<0.05), the level of P-LPO and ROS were lower in the experimental group than in the control group (P<0.05), and the level of S100B, MMP-9, pNF-H, and GFAP water was lower in the experimental group than in the control group (P<0.05). The time to recovery of primitive reflexes, time to recovery of muscle tone, time to recovery of voluntary suckling, time to recovery of consciousness, and days of hospitalization were shorter in the test group than in the control group (P<0.05), and the NB-NA elevation score was higher in the test group than in the control group (P<0.05). Conclusion: Compared with the basic treatment and caffeine citrate treatment, the combination of caffeine citrate and subhypothermia treatment for preterm infants with brain injury can reduce inflammatory factors in the body, inhibit the inflammatory response, improve patients' oxidative stress levels, reduce oxygen-free radical damage, reduce S100B, MMP-9, pNF-H, and GFAP levels, enhance patients' neurological function and promote their recovery.
|
|
|
|
|
|
[1] 魏佳.沉默信息调节因子3调控小胶质细胞对早产儿脑损伤的神经保护作用研究进展[J].临床儿科杂志,2021,39(2):152-156.
[2] 单继艳.不同剂量重组人促红细胞生成素治疗早产儿脑损伤疗效及安全性探讨[D].江苏:江苏大学,2016.
[3] 姚彦莉,张国斐,王斐,等.血清髓磷脂碱性蛋白、缺氧诱导因子-1α及S100B对脑损伤早产儿病情及预后的评估价值[J].中国临床医生杂志,2021,49(8):985-988.
[4] 中国医师协会新生儿专业委员会.早产儿脑损伤诊断与防治专家共识[J].中国当代儿科杂质,2012,14(12):883-884.
[5] 张名扬,宋磊.早产儿脑损伤发病机制的进展[J].南通大学学报(医学版),2021,41(4):349-352.
[6] Van der Laan M E,Roofthooft M T,Fries M W,et al.Multisite tissue oxygenation monitoring indicates organ-specific flow distribution and oxygen delivery related to low cardiac output in preterm infants with clinical sepsis[J].Pediatr Crit Care Med,2016,17(8):764-771.
[7] 沙宁,明葛东,杨娟,等.神经节苷脂联合rhuEPO对低氧性脑损伤早产儿血清UCH-L1、GFAP、MBP、TLR-4的影响[J].脑与神经疾病杂志,2019,27(10):640-644.
[8] 李海燕,秦道建,张士发.NSE、LDH和CK联合检测对早产儿脑损伤早期诊断的价值[J].皖南医学院学报,2018,37(5):433-436.
[9] 赵莹,徐艳,吴铭,等.pNF-H、MMP-9联合aEEG对早产儿脑损伤的早期预测价值[J].中国生育健康杂志,2021,32(4):324-329.
[10] 王涛,李玉凤,王昕升,等.血清HMGB1、GFAP、UCH-L1对窒息早产儿脑损伤的诊断价值[J].国际检验医学杂志,2021,42(13):1549-1553. |
|
|
|
2022, Vol. 28 
