先天性甲状腺功能减低症患儿血清IGF-1 IGFBP-3和Hcy水平变化及其与体格发育的关系

doi:10.3969/j.issn.1006-6233.2022.09.014

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Abstract Objective: To investigate the changes in serum insulin growth factor-1 (IGF-1),insulin-like growth factor binding protein-3 (IGFBP-3) and homocysteine (Hcy) levels in children with congenital hypothyroidism (CH) and their relationship with physical development. Methods: One hundred and ten children with CH who received replacement therapy at our hospital (observation group) and 59 normal newborns at the same time (healthy control group) were selected as study subjects.Both groups were followed up for 1 year.The differences in levels of serum IGF-1,IGFBP-3 and Hcy and physical development indicators [height,body mass,height standard deviation score (HtSDS),weight standard deviation score (WTSDS)] were compared between observation group and healthy control group at enrollment and after 1 year of follow-up.Pearson correlation analysis was used to analyze the correlation between levels of serum IGF-1,IGFBP-3 and Hcy and physical development indicators of children patients with CH after 1 year of follow-up. Results: There were no significant differences between the two groups in terms of gender,age,delivery methods and maternal birth age (all P>0.05),and the TSH level of observation group was significantly higher than that of healthy control group (P<0.05) while the levels of FT3 and FT4 were significantly lower than those in control group (P<0.05).The levels of IGF-1 and IGFBP-3 in observation group and healthy control group after 1 year of follow-up were higher than those at enrollment (P<0.05) while the level of Hcy was significantly lower than that at enrollment (P<0.05).At enrollment and after 1 year of follow-up,the levels of serum IGF-1 and IGFBP-3 in observation group were lower than those in healthy control group (P<0.05) while the level of serum Hcy was higher (P<0.05).At enrollment,there were no statistically significant differences in the height,body mass,HtSDS and WTSDS between the two groups (P>0.05).The height and body mass in observation group and healthy control group after 1 year of follow-up were higher than those at enrollment (P<0.05),and the height and body weight of healthy control group were higher or heavier than those of observation group (P<0.05).According to Pearson correlation analysis,levels of serum IGF-1,IGFBP-3 and Hcy in children with CH were not correlated with HtSDS and WTSDS (P>0.05),but levels of IGF-1 and IGFBP-3 were positively correlated with height and body mass (all P<0.05),and Hcy level was negatively correlated with height and body mass (all P<0.05). Conclusion: The levels of serum IGF-1,IGFBP-3 and Hcy in children with CH after replacement therapy have been significantly improved,and they have a significant correlation with physical development.

Key words： Congenital hypothyroidism Serum insulin-like growth factor-1 Insulin-like growth factor binding protein-3 Homocysteine Physical development

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.09.014 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I9/1479

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