糖尿病肾病患者血清ICAM-1 VCAM-1及CTRP9表达水平与冠脉血管钙化的关系

doi:10.3969/j.issn.1006-6233.2022.08.09

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Abstract Objective: To explore the association of the expression levels of serum intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and complement C1q tumor necrosis factor related protein 9 (CTRP9) with coronary vascular calcification in patients with diabetic kidney disease (DKD). Methods: Totally 152 patients with DKD were selected between May 2019 and October 2021, and were divided into calcification group (68 cases) and non-calcification group (84 cases) according to whether they were complicated with coronary calcification. The general data, related biochemical indicators and levels of serum ICAM-1, VCAM-1 and CTRP9 (measured by enzyme-linked immunosorbent assay) were compared between the two groups. Multivariate Logistic regression analysis was used to explore the influencing factors of coronary vascular calcification in DKD, and ROC curves were plotted to explore predictive value of serum ICAM-1, VCAM-1 and CTRP9 levels on vascular calcification in DKD. Results: The proportion of DKD clinical stage in calcification group was higher than that in non-calcification group (P<0.05), but there were no statistical differences in gender, age, body mass index, smoking history, drinking history and duration of diabetes mellitus between the two groups (P>0.05). The levels of HbA1c, LDL-C, blood calcium and mAlb were higher in calcification group than in non-calcification group (P<0.05), but the differences in the levels of TG, TC, HDL-C, blood phosphorus, BUN and SCr were not statistically significant between the two groups (P>0.05). Serum ICAM-1 and VCAM-1 levels in calcification group were significantly higher than those in non-calcification group (P<0.05), while the CTRP9 level was significantly lower than that in the non-calcification group (P<0.05). Clinical stage of DKD and high levels of HbA1c, ICAM-1 and VCAM-1 were the risk factors for coronary vascular calcification in patients with DKD (P<0.05), and high level of CTRP9 was a protective factor (P<0.05). The areas under the ROC curves of serum ICAM-1, VCAM-1 and CTRP9 on predicting vascular calcification in DKD were 0.710, 0.761 and 0.752 (P<0.05). Conclusion: The expressions of serum ICAM-1 and VCAM-1 are increased, while the expression of CTRP9 is decreased in patients with DKD complicated with coronary vascular calcification. The detection of the three levels has certain predictive value on coronary vascular calcification in DKD.

Key words： Diabetic kidney disease Coronary vascular calcification Intercellular adhesion molecule-1 Vascular cell adhesion molecule-1 Complement C1q tumor necrosis factor related protein 9

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	HOU Rui
	HU Wei
	DONG Pei
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HOU Rui,HU Wei,DONG Pei, et al. Association of Serum ICAM-1 VCAM-1 and CTRP9 Expression Levels with Coronary Vascular Calcification in Patients with Diabetic Nephropathy[J]. HeBei Med, 2022, 28(8): 1279-1284.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.08.09 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I8/1279

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