不同剂量帕瑞昔布钠对直肠癌手术患者免疫指标血清S100β NSE TNF-α及IL-1β水平的影响

doi:10.3969/j.issn.1006-6233.2022.08.035

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Abstract Objective: To investigate the Effect of different doses of parecoxib sodium on immune indexes, serum S100β, NSE, TNF-α and IL-1β levels in patients undergoing surgery for rectal cancer. Methods: A total of 80 patients who underwent rectal cancer surgery in our hospital from March 2018 to June 2021 were included in the study. They were simply randomly divided into high-dose, low-dose and control groups, with 30 cases, 30 cases and 20 cases respectively. The control group was treated with sodium chloride (0.9%) 20 minutes before anesthesia , the high-dose group was given 30 mg parecoxib sodium, and the low-dose group was given 10 mg parecoxib sodium β , NSE , TNF- α And IL-1 β. Results: The number of analgesic pump presses was significantly less in the high-dose group than in the low-dose and control groups, and significantly less in the low-dose than in the control group, with statistically significant differences (P<0.05); the differences were statistically significant (P<0.05) for the comparison of intersubject effects (F time point, F interaction) and between-subject effects (F between groups) for S100β, TNF-α, IL-1β, and NSE only for the F time point comparison was statistically significant (P<0.05), while the between-group differences and group-time-interaction effects were not statistically significant (P>0.05). The differences were statistically significant (P<0.05) for the comparison of CD3⁺ and CD4⁺ within-subject effects (F time point, F interaction) and between-subject effects (F between groups), and statistically significant (P<0.05) for CD8⁺ only for the comparison of F time point, while neither the between-group differences nor the interaction between groups and time were statistically significant (P>0.05). Conclusion: Parecoxib sodium significantly improved immune markers, serum S100β, NSE, TNF-α and IL-1β levels in patients undergoing surgery for rectal cancer, with better results when 30mg was used.

Key words： Parecoxib sodium Rectal cancer Immune index Serum S100 β Inflammatory factor

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.08.035 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I8/1399

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