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| Clinical Significance of Serum MiR-17 and MiR-25 Expression in Patients with Preeclampsia and Its Influence on Pregnancy Outcome |
| CHEN Zhiping, HUANG Lishan, WU Mingxiu, et al |
| Dongguan Hospital Affiliated to Southern Medical University / Dongguan People's Hospital, Guangdong Dongguan 523000, China |
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Abstract Objective: To explore the clinical significance of serum microRNA-17 (miR-17) and miR-25 expression in patients with preeclampsia (PE) and its influence on pregnancy outcome.Methods: Seventy-four cases of PE patients in our hospital from February 2018 to August 2020 were selected as the PE group, and 74 cases of normal pregnant women without pregnancy comorbidities and complications were selected as the healthy group during the same period. The general data and serum miR-17 and miR-25 levels of the two groups were compared, and the diagnostic value of serum miR-17 and miR-25 levels in relation to the occurrence of PE level on PE was analyzed, and the correlation between serum miR-17 and miR-25 levels and clinical characteristics and pregnancy outcome of PE patients was analyzed. Results: The diastolic blood pressure, systolic blood pressure, and serum miR-17 levels in the PE group were higher than those in the healthy group, and week of delivery, neonatal birth weight, and serum miR-25 levels were lower than in the healthy group (P<0.05); logistic regression analysis showed that serum miR-17 and miR-25 levels were correlated with PE (P<0.05);receiver operating characteristic (ROC) curve shows that the AUC for the combined diagnosis of PE with miR-17 and miR-25 was the largest at 0.918; there were significant differences in diastolic blood pressure, systolic blood pressure, gestational week of delivery, and neonatal birth weight among patients with PE with different serum miR-17 and miR-25 levels (P<0.05); miR-17 and miR-25 expression levels were associated with clinical characteristics (diastolic blood pressure, systolic blood pressure) and pregnancy outcome (gestational week of delivery, neonatal birth weight (P<0.05).Conclusion: Serum miR-17 and miR-25 of PE patients are expressed pathologically, and they are related to the severity of the disease and pregnancy outcome.
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[1] Thalor N,Singh K,Pujjani M,et al.A correlation between platelet indices and preeclampsia[J].Hematol Transfus Cell Ther,2019,41(2):129-133.
[2] Ospina-prieto S,Chaiwangyen W,Herrmann J,et al.MicroRNA-141 is upregulated in preeclamptic placentae and regulates trophoblast invasion and intercellular communication[J].Transl Res,2016,172(1):61-72.
[3] 李晖,焦顺,郑晓丹,等.子痫前期胎盘组织miRNA差异表达谱生物学分析及miR-365a-3p参与发病的机制探讨[J].山东医药,2020,60(11):29-33.
[4] 王能,王志宇,张奉学,等.乳腺癌干细胞相关miRNA的高通量筛选及miR-25介导自噬对乳腺癌干细胞的调控作用[J].医学综述,2020,26(4):792-799.
[5] 万淑梅,彭萍,高妍.miR-181a-5p调控IGF2BP2表达对胎盘滋养层细胞浸润、迁移能力的影响及机制[J].山东医药,2020,60(2):22-26.
[6] 许燕滨.miR-17-5p调控MCL-1与子痫前期的相关性研究[D].广东:南方医科大学,2018.
[7] 张风江,周金桥,赵新炜,等.微小RNA-17-5p在脑恶性胶质瘤患者血清和肿瘤组织的表达及其对U87MG和U251体外作用[J].中华实验外科杂志,2017,34(7):1206-1209.
[8] 李苑艳,王智慧,孙素玉.内脂素、TNF-α与子痫前期患者血糖及胰岛素的关系[J].中国妇幼健康研究,2019,30(2):182-185.
[9] Wu MZ,Cheng WC,Chen SF,et al.miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS[J].Nat Cell Biol,2017,19(10):1286-1296.
[10] 万淑梅,彭萍,高妍.血清PTEN水平与子痫前期患者氧化应激及妊娠结局的关系[J].中国医药导报,2019,16(33):96-99.
[11] 潘蓉,杨静,张铭,等.circRNA_001131通过结合miR-25-3p抑制心肌成纤维细胞中纤维化相关基因的表达[J].中国病理生理杂志,2020,36(1):1-8. |
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2022, Vol. 28 
