全脑放疗对肺癌脑转移瘤近期神经认知功能及预后的影响分析

doi:10.3969/j.issn.1006-6233.2022.08.013

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Abstract Objective: To explore the effect of whole brain radiotherapy (WBRT) on recent neurocognitive function and prognosis of patients with lung cancer brain metastasis, and to analyze the safety of WBRT in the treatment of lung cancer brain metastasis.Methods: A retrospective study was conducted with a selection of 91 patients with lung cancer brain metastases treated in our hospital from January 2017 to October 2021. All patients were treated with WBRT. The recent neurocognitive function of patients before and after treatment was compared. A 4-month outpatient or telephone follow-up observation was conducted to record the survival and death status of patients. They were divided into survival group and death group. The factors affecting the death of patients were analyzed by Cox regression.Results: There were significant differences in neurocognitive function before and after treatment. After treatment, the speed of language memory, visual memory, attention, and information processing was significantly better (P<0.05). After 91 patients were treated with WBRT, 45 patients died within 4 months after discharge through follow-up investigation. As of the end of follow-up, 46 patients were in a state of survival, and the case fatality rate was 49.45% 4 months after discharge. Compared with the dead patients, the proportion of squamous cell carcinoma and adenocarcinoma was larger, the proportion of small cell carcinoma was smaller, and the proportion of extracranial metastasis, deep metastasis, and uncontrolled primary tumor was less in the surviving patients (P<0.05). Cox regression analysis showed that histological diagnosis, extracranial metastasis, depth of metastatic tumor, and control of primary tumor were significantly correlated with the prognosis of patients with brain metastasis of lung cancer after treatment (P<0.05). Conclusion: WBRT treatment improves the neurocognitive function of patients with brain metastasis from lung cancer. Histological diagnosis, extracranial metastasis, depth of metastasis, and control of primary tumor are the risk factors affecting the prognosis of patients.

Key words： Whole brain radiotherapy Lung cancer Brain metastasis Neurocognitive function Prognosis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.08.013 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I8/1298

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