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| The Application of 1.5T Magnetic Resonance Diffusion Weighted Imaging in the Diagnosis of Rectal Cancer and Its Relationship with MVD, VEGF and LVD |
| ZENG Fangyi, YANG Zhangzhe, WANG Kun, et al |
| Danzhou People's Hospital, Hainan Danzhou 571700, China |
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Abstract Objective: To explore the application of 1.5T magnetic resonance diffusion weighted imaging (DWI) in rectal cancer and the relationship between apparent diffusion coefficient (ADC value) and microvessel density (MVD), vascular endothelial growth factor (VEGF) and lymphatic vessel density (LVD). Methods: The clinicopathological data of 86 patients with rectal cancer admitted to our hospital from April 2018 to April 2021 were retrospectively selected. All patients were examined by DWI before treatment, and their MVD, VEGF and LVD expression levels were measured by immunohistochemistry. The value of DWI in the diagnosis of rectal cancer, and the relationship between ADC value and MVD, VEGF and LVD with Person correlation were analyzed. Results: ADC values were higher in patients with highly differentiated, T2 and N0 rectal cancers than those with low+moderately differentiated, T4 and N1~2 stages (P<0.05), but MVD, VEGF and LVD expression were lower in patients with highly differentiated, T2 and N0 rectal cancers than those with low+moderately differentiated, T4 and N1~2 stages. Person correlation showed that ADC values were negatively correlated with MVD, VEGF and LVD (r=-0.428, -0.505, -0.474, P<0.05). ROC results showed that ADC values predicted the degree of differentiation, T-stage and N-stage of rectal cancer with AUCs of 0.904, 0.839 and 0.897, respectively.Sensitivity and specificity: 83.3% and 87.8% for differentiation, 68.4% and 89.6% for T-stage and 91.9% and 85.7% for N-stage. Conclusion: The sensitivity and specificity of 1.5T MRI DWI sequences in predicting T-stage, N-stage and differentiation degree of rectal cancer are high, and the ADC values are closely related to MVD, VEGF and LVD expression, which can provide a reference basis for clinical treatment and prognosis assessment.
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2022, Vol. 28 
