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| Correlation Between Type 2 Diabetes Mellitus and Urinary Stone Species |
| WU Yang, WANG Xing, CHEN Ling, et al |
| The Second Affiliated Hospital of Chengdu Medical College·416 Hospital of Nuclear Industry, Sichuan Chengdu 610051, China |
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Abstract Objective: To analyze the correlation between type 2 diabetes mellitus (T2DM) and urinary stone species. Methods: One hundred and sixty-five patients with urinary calculi treated admitted in our hospital from January 2019 to December 2021 were enrolled for the research and divided into T2DM group (n = 35) and non-T2DM group (n = 130) according to the occurrence of T2DM before operation. The stone components were analyzed and compared between the two groups by infrared spectroscopy, and the influencing factors of uric acid stones were analyzed by logistic multivariate regression. Results: Calcium oxalate was the most common type of stones in T2DM group and non-t2dm patients, accounting for 48.5% (17/35) and 66.2% (86/130) respectively, followed by uric acid stones, accounting for 28.6% (10/35) and 10.0% (13/130) respectively. There was significant difference in the stone components between the two groups (P < 0.05), and the proportion of uric acid stones in T2DM group was significantly higher than that in non-T2DM group, but there were no significant differences in the proportions of other three stone components between two groups. We further divided all 165 patients with urinary calculi into uric acid calculi group (n = 23) and non-uric acid calculi group (n = 142). The age, body mass index, proportion of hypertension history, proportion of T2DM history, fasting blood glucose, blood triglyceride, uric acid, albumin and serum creatinine (SCr) levels in the uric acid stone group were significantly higher than those in the non-uric acid stone group, and the urine pH in uric acid stone group was significantly lower than that in non-uric acid stone group (P < 0.05). Result of multivariate logistic regression analysis showed that T2DM, blood uric acid, SCr level and urinary pH were the independent influencing factors of uric acid stones (P < 0.05). Conclusion: The stone species of patients with urinary calculi is related to T2DM, and patients with T2DM are more prone to uric acid stones, which is worthy of clinical attention.
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[1] 杨雄,安能,杨瑞,等.糖尿病与泌尿系统结石关系的研究进展[J].实用医学杂志,2019,35(15):2499-2503.
[2] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2020年版)[J].中华糖尿病杂志,2021,13(4):315-409.
[3] 黄跃胜,黄海鹏,朱心燊.输尿管镜下钬激光碎石术对结石清除率术后并发症及临床疗效的影响[J].河北医学,2017,23(1):152-154.
[4] 常学良,王亚轩,李景东,等.河北省不同地理环境上尿路结石成分分布特点研究[J].中国全科医学,2022,25(2):171-174.
[5] 陈雪花,周月,徐彦,等.红外光谱法对22750例泌尿系结石成分分析[J].泌尿外科杂志(电子版),2021,13(2):36-39.
[6] 李杰.代谢综合征与泌尿系结石关系的研究进展[J].天津医科大学学报,2017,23(6):576-578.
[7] 罗敏,苟淼,沈鹏飞,等.代谢综合征与泌尿系结石的危险因素及结石成分的关系[J].四川医学,2018,39(2):138-141.
[8] 林甫俊,王忠康,潘建刚.代谢综合征与泌尿系结石的研究进展[J].国际泌尿系统杂志,2019,39(3):553-555. |
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2022, Vol. 28 
