外周血NLR Gal-9表达与子宫内膜异位症患者盆腔疼痛及粘连的相关性分析

doi:10.3969/j.issn.1006-6233.2022.06.08

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Abstract Objective: To explore and analyze the correlation between the expression of NLR and Gal-9 in peripheral blood and pelvic pain and adhesions in patients with endometriosis. Methods: A total of 124 patients with endometriosis who underwent surgical treatment in our hospital from July 2019 to July 2020 were selected as the observation group and 60 patients with non-endometriosis who were hospitalized during the same period were selected as the control group. During the operation, the clinical stage of the patients was determined according to the American Residual Association's revised standard staging method (RAFS), and the pelvic pain degree of the patients was graded according to the pain degree classification method (VRS), and the pelvic viscosity degree was graded according to the Hobson score method. The peripheral blood neutrophil-to-lymphocyte ratio (NLR) was calculated based on the results of routine blood tests, and the level of galactose lectin-9 (Gal-9) was measured using a double antibody sandwich enzyme immunoassay to analyse the correlation between its expression level and the patients' pelvic pain and adhesions. Results: The peripheral blood NLR (2.67±0.64) and Gal-9 (687.34±126.51) ng/L levels of the observation group were significantly higher than those of the control group (2.13±0.38) and (329.56±94.23) ng/L, and the difference reached statistical significance ( P<0.05); the expression levels of NLR and Gal-9 in peripheral blood of patients in the severe pelvic pain group were significantly higher than those in the pelvic moderate pain group and mild pain group, and the difference between the groups was statistically significant (P<0.05); the expression levels of NLR and Gal-9 in peripheral blood were significantly higher in the group with severe pelvic adhesions than in the group with mild pelvic adhesions, and the difference between the groups reached statistical significance (P<0.05); the expression of NLR and Gal-9 in peripheral blood was included in the logistic regression equation, and the results showed that the expression of NLR and Gal-9 in peripheral blood was positively correlated with the degree of endometriosis (P<0.05). Conclusion: The expression of NLR and Gal-9 in peripheral blood is positively correlated with the degree of pelvic pain and adhesion in patients with endometriosis. The detection of their levels can provide guidance for early diagnosis and evaluation of disease severity in patients with endometriosis.

Key words： Neutrophil to lymphocyte ratio Galectin-9 Endometriosis Pelvic pain Pelvic adhesions

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.06.08 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I6/914

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