胺碘酮联合美托洛尔治疗急性心肌梗死并发心律失常疗效及对血清炎症因子氧化应激和血管内皮功能的影响

doi:10.3969/j.issn.1006-6233.2022.06.035

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Abstract Objective: To investigate the clinical effects of amiodarone combined with metoprolol in the treatment of acute myocardial infarction complicated with arrhythmia, and its influence on serum inflammatory factors, oxidative stress and vascular endothelial function. Methods: Totally 116 patients with acute myocardial infarction complicated with arrhythmia who were admitted to the hospital between September 2017 and October 2020 were randomly divided into amiodarone group (n=38), metoprolol group (n=38), and combination group (amiodarone combined with metoprolol, n=40). Serum inflammatory factors, oxidative stress, vascular endothelial function and adverse reactions were compared between the groups. Results: The total clinical response rate in the combination group (92.50%) was higher than that in the amiodarone group (78.95%) or the metoprolol group (76.32%) (P<0.05). After treatment, the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), endothelin-1 (ET-1), von Willebrand factor (vWF), and malondialdehyde (MDA) were significantly decreased, while the levels of serum nitric oxide (NO), superoxide dismutase (SOD), and glutathione peroxidase (GPX) were significantly increased in the three groups. The decreases or increases of the combination group were significantly greater than those of the other two groups (P<0.05). The incidence of adverse reactions was 12.50% in the study group, 15.79% in the amiodarone group, and 18.42% in the metoprolol group (P>0.05). Conclusion: Amiodarone combined with metoprolol is markedly effective in the treatment of acute myocardial infarction complicated with arrhythmia. It can effectively reduce the levels of serum inflammatory factors, and improve oxidative stress response and vascular endothelial function in the patients, with good safety.

Key words： Acute myocardial infarction Arrhythmia Amiodarone Metoprolol Inflammatory factor Oxidative stress Vascular endothelial function

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	HE Ruiying
	LIAO Hui
	LI Luna

Cite this article:

HE Ruiying,LIAO Hui,LI Luna. Curative Effect of Amiodarone Combined with Metoprolol in the Treatment of Acute Myocardial Infarction Complicated with Arrhythmia and Its Influence on Serum Inflammatory Factors Oxidative Stress and Vascular Endothelial Function[J]. HeBei Med, 2022, 28(6): 1037-1040.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.06.035 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I6/1037