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| Prognostic Value of Central Venous-to-Arterial Carbon Dioxide Difference, Lactate and Procalcitonin in Septic Shock Patients |
| YAN Si, ZHAN Wenshi, YAN Guanghuan, et al |
| Qionghai People's Hospital, Hainan Qionghai 571400,China |
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Abstract Objective: To explore the prognostic value of central venous-to-arterial carbon dioxide difference [P(cv-a)CO2], lactate and procalcitonin (PCT) in septic shock patients. Methods: The data of 141 septic shock patients admitted to the hospital between October 2017 and October 2020 was collected. The patients were divided into survival group (71 cases) and death group (70 cases) according to the prognosis. Multivariate logistic regression analysis was performed to analyze the relationship of serum P(cv-a)CO2, lactate and PCT levels with death of septic shock patients. Meanwhile, ROC curve analysis of serum P(cv-a)CO2, lactate and PCT levels was conducted. Results: The levels of P(cv-a)CO2, lactate and PCT in survival group were lower than those in death group (P<0.05). Multivariate logistic regression analysis found that serum P(cv-a)CO2, lactate and PCT were risk factors for death of patients with septic shock (P<0.05). ROC curve analysis showed that the area under the curve (AUC) values of serum P(cv-a)CO2, lactate and PCT to predict the prognosis were 0.951, 0.958, and 0.971, respectively. The 95%CIs were 0.901-0.980, 0.910-0.984, and 0.928-0.992. The cutoff values were 5.974, 5.257 and 9.381. The sensitivity was 87.142%, 90.001% and 92.861%. The specificity was 88.731%, 91.552% and 91.552 %. Conclusion: High serum levels of P(cv-a)CO2, lactate and PCT are related to poor prognosis of septic shock patients. All of the three have good prognostic value in septic shock patients.
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[1] 张苜,甯议万,范晶,等.早期临床免疫学监测在脓毒症患者预后评估中的价值探讨[J].重庆医科大学学报,2019,44(1):80-84.
[2] 王静波,燕宪亮,王厚清,等.血清microRNA-25对脓毒症患者病情严重程度及预后的评估价值[J].临床急诊杂志,2020,21(6):78-83.
[3] 孙才智,仲伯蒙,沈华,等.血清甲状腺激素对脓毒症休克患者短期预后的预测价值[J].中华急诊医学杂志,2021,30(2):183-188.
[4] linger RP,Levy MM,Rhodes A,et al.Surviving sepsis cam-paign:international guidelines for management of severe sepsis andseptic shock,2012[J].Intensive Care Med,2013,39(2):165-228.
[5] 方红龙,陈娟,罗建,等.经皮-动脉血二氧化碳分压差在脓毒性休克液体复苏中的变化及意义[J].中国中西医结合急救杂志,2019,26(5):529-532.
[6] 牛杏果,张思森,焦宪法,等.ScvO2联合P(cv-a)CO2监测在感染性休克患者液体复苏中的指导意义及对预后的影响[J].中国急救医学,2019,39(10):939-944.
[7] 王见斌,孟令胜,陆丽丽,等.动静脉二氧化碳分压差在脓毒性休克液体复苏中的应用[J].中华保健医学杂志,2020,22(3):180-183.
[8] 郝翠平,胡庆河,朱丽娜,等.血乳酸和降钙素原与病情严重程度评分对脓毒性休克患者短期预后的联合预测价值[J].中华危重病急救医学,2021,33(3):281-285.
[9] 安春霞,则学英,唐山宝,等.NT-proBNP,CRP,PCT对脓毒症及脓毒症休克患者病情及预后的评估价值[J].中国病案,2020,021(4):98-102. |
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2022, Vol. 28 
