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| Correlation between Serum Interleukin-6 Level and Myocardial Damage in Paediatric Mycoplasma Pneumonia |
| XU Li, ZHANG Rui, SHI Qingkang, et al |
| No.901 Hospital,Joint Logistics Support Force of the Chinese People's Liberation Army, Anhui Hefei 230009, China |
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Abstract Objective: To analyze the correlation between serum Interleukin-6 (IL-6) level and myocardial damage (MD) in paediatric mycoplasma pneumonia (MPP). Methods: One hundred and thirty-eight children with MPP treated in our hospital from June 2019 to June 2021 were enrolled for the research and divided into MD group and non-MD group according to the disease process. The gender, age, blood leukocyte (WBC), procalcitonin (PCT), C-reactive protein (CRP), creatine kinase-MB isoenzyme (CK-MB), cardiac troponin I (cTnI), IL-6 levels and hospitalization time were compared between the two groups. The area under the curve (AUC) of receiver operating characteristic (ROC) curve was performed to evaluate the diagnostic value of these indexes for MD. Pearson correlation was used to analyze the relationship between serum IL-6 level and hospitalization time. Results: Myocardial damage occurred in 33 of 138 children, with an incidence of 23.9%. The serum levels of CRP, PCT, CK-MB, cTnI, IL-6 and hospitalization time in MD group were significantly higher than those in non-MD group (P<0.05). There were no significant differences in gender, age and WBC between two groups (P>0.05). The results of ROC curve showed that IL-6, CK-MB and cTnI had high diagnostic value for myocardial damage (AUC > 0.9) while CRP and PCT had certain diagnostic value (AUC 0.7 ~ 0.9), but age and WBC had no obvious diagnostic value (AUC < 0.7). Pearson correlation analysis showed that the serum IL-6 level of all children was significantly positively correlated with the length of hospital stay (r = 0.328, P = 0.001 <0.05). Conclusion: Serum level of IL-6 has a potential diagnostic value for the occurrence of myocardial damage in children with MPP, and it is related to the length of hospital stay, which is worthy of clinical reference.
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2022, Vol. 28 
