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| The Mechanism of "Renshen-Maidong" in the Treatment of Antineoplastic Drug-Induced Cardiotoxicity |
| YANG Mengxia, et al |
| Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China |
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Abstract Objective: To investigate the mechanism of "Renshen-Maidong" drug pair in the treatment of antineoplastic drug-induced cardiotoxicity (ADIC) by network pharmacology. Methods: TCMSP, TCMID and TCM Database@Taiwan databases were used to screen the main active ingredients of the drugs. Swiss Target database was used to search the drugs-related targets. GengCards and DisGeNet databases were used to collect the ADIC-related disease genes. Drug targets and disease genes were subjected to Venny analysis, and enrichment analysis was performed in DAVID database. The multi-level network "herbs-effective components-targets-pathways" was constructed by Cytoscape software, and the core genes were screened out.Results: There were 42 main active ingredients in "Renshen-Maidong", which contained 769 targets, and 354 ADIC genes, of which 102 were potential targets of "Renshen-Maidong" for the treatment of ADIC. Through enrichment analysis, it was found that "Renshen-Maidong" exerted cardioprotective effects through VEGF, TNF, ErbB and other signaling pathways in the treatment of ADIC. The important genes of "Renshen-Maidong" in treating ADIC are SRC, CASP3, STAT3, and MAPK1/14 and so on.Conclusion: We constructed the network "herbs-effective components-targets-pathways" through network pharmacology, and found that the mechanism of action of "Renshen-Maidong" in treating ADIC involves multiple targets and pathways, which may be related to antioxidant stress, anti inflammation, anti apoptosis, and promoting angiogenesis, etc.
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2022, Vol. 28 
