腹股沟疝无张力修补术后血清IL-17 IL-8 hs-CRP及TIMP-2水平与预后关系

doi:10.3969/j.issn.1006-6233.2022.04.021

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Abstract Objective: To explore the relationship between serum interleukin 17 (IL-17), interleukin 8 (IL-8), hypersensitive C-reactive protein (hs-CRP) and tissue inhibitor of metalloproteinase (TIMP-2) levels and prognosis after tension-free inguinal hernia repair. Methods: A total of 135 inguinal hernia patients who underwent tension-free hernia repair from June 2019 to June 2020 in our hospital were selected for the study. All patients were followed up for 12 months after surgery and were divided into a good prognosis group ( 111 cases) and poor prognosis group (24 cases) based on postoperative complications and recurrence. The serum levels of IL-17, IL-8, hs-CRP and TIMP-2 were compared between the two groups, and receiver operating curve (ROC) analysis were used to determine their relationship with prognosis.Results: The levels of serum IL-17, IL-8 and hs-CRP in the poor prognosis group were higher than those in the good prognosis group, and the TIMP-2 level was lower than that in the good prognosis group, and the differences were statistically significant (P<0.05). ROC curve analysis showed that the AUCs of IL-17, IL-8, hs-CRP, and TIMP-2 in predicting poor prognosis after tension-free repair of inguinal hernia were 0.967 (0.924~1.000), 0.792 (0.690~0.895), 0.827 (0.739~0.915), 0.960 (0.925~0.996), and the Z test AUC difference showed that the AUC of IL-17 was significantly higher than that of IL-8 and hs-CRP (Z=3.099, 2.795, P＜0.05), AUC of TIMP-2 was significantly higher than that of IL-8 and hs-CRP (Z=3.053, 2.744, P<0.05). According to the optimal cutoff value, IL-17 (42.41ng/L) and IL-8 (25.43ng/L) , hs-CRP (40.14mg/L), and TIMP-2 (70.72μg/L) were 95.8%, 91.7%, 95.8%, 91.9%, and the specificities were 90.1%, 54.1%, 64.9%, 91.7%, respectively.Conclusion: Serum IL-17, IL-8, hs-CRP after tension-free repair of inguinal hernia are positively correlated with poor prognosis, and TIMP-2 levels are negatively correlated with poor prognosis, and all have a certain predictive value for poor prognosis. Among them, IL-17 , TIMP-2 has a higher predictive value.

Key words： Inguinal hernia Tension-free repair Interleukin 17 Interleukin 8 High-sensitivity C-reactive protein Tissue metalloproteinase inhibitor Prognosis

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	TANG Yong
	ZHAO Yang
	HE Bing

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TANG Yong,ZHAO Yang,HE Bing. Relationship Between Serum IL-17 IL-8 hs-CRP and TIMP-2 Levels and Prognosis After Tension-Free Inguinal Hernia Repair[J]. HeBei Med, 2022, 28(4): 634-638.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.04.021 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I4/634

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