血清TSH MPO 铁蛋白在甲状腺功能减退症中的表达及相关性

doi:10.3969/j.issn.1006-6233.2022.04.018

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Abstract Objective: To investigate the expression and correlation of serum thyrotropin (TSH), myeloperoxidase (MPO) and ferritin in hypothyroidism. Methods: From May 2019 to May 2020, 337 patients with hypothyroidism admitted to our hospital were selected as the observation group, and 350 patients with normal thyroid function were selected as the control group during the same period. TSH and ferritin levels were measured by Roche E601 automatic electrochemiluminescence immunoassay analyzer and its supporting kit, and serum MPO expression was measured by double antibody sandwich ELISA in both groups to analyze the expression and correlation of TSH, MPO and ferritin in hypothyroid patients. Results: Compared to the control group, serum TSH and MPO were increased and ferritin, free triiodothyronine (FT3) and free thyroxine (FT4) levels were decreased in the observation group (P<0.05); correlation analysis was performed with TSH, MPO and ferritin expression. TSH and MPO were positively correlated (r=0.458/P=0.001), TSH and ferritin were negatively correlated (r=-0.368/P=0.001), MPO and ferritin were negatively correlated (r=-0.343/P=0.001); TSH and MPO were negatively correlated with changes in thyroid hormones (FT3 and FT4) in hypothyroid patients, while ferritin was positively correlated with changes in thyroid hormones in hypothyroid patients. TSH, MPO and ferritin were included in a dichotomous multi-factor logistic regression model analysis, and the results showed that TSH and MPO were risk factors and ferritin was a protective factor for the development of hypothyroidism (P<0.05). Conclusion: Serum TSH and MPO are abnormally high in hypothyroidism, and ferritin is abnormally low in hypothyroidism, which are involved in the evolution of the disease, and their detection can provide a certain reference for the diagnosis and treatment of clinical hypothyroid patients.

Key words： Thyrotropin Myeloperoxidase Ferritin Hypothyroidism

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.04.018 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I4/619

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