|
|
|
| The Expression and Clinical Significance of NAMPT and Mir-206 in Serum of Patients with Chronic Heart Failure |
| HA Sigaowa, WU Jisiguleng |
| The Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Hohhot 010050, China |
|
|
|
|
Abstract Objective: To investigate the expression and clinical significance of nicotinamide phosphoribose transferase (NAMPT) and mir-206 in the serum of patients with chronic heart failure. Methods: Seventy-six patients with chronic heart failure who were treated in our hospital from January 2020 to August 2021 were selected as the heart failure group. In addition, 34 healthy people who underwent physical examination in this hospital during the same period were selected as the healthy group. Enzyme-linked immunosorbent assay was used to detect the level of NAMPT in serum, real-time fluorescent quantitative PCR method to detect the level of serum mir-206; the cardiac function of patients was graded, the serum levels of NAMPT and mir-206 in patients with different cardiac function classes were compared, the correlation between NAMPT, mir-206 levels and left ventricular end diastolic diameter (LVEDD), B-type natriuretic peptide (BNP), left ventricular ejection fraction (LVEF) was analyzed, and the receiver operating characteristic curve (ROC) was used to analyze the predictive value of serum NAMPT and mir-206 levels in patients with chronic heart failure.Results: The levels of NAMPT, LVEDD and BNP in the heart failure group were higher than those in the healthy group (P<0.05), and the levels of mir-206 and LVEF were lower than those in the healthy group (P<0.05); the level of NAMPT in serum of patients with chronic heart failure gradually increased with the increase of cardiac function classification (P<0.05), and the level of mir-206 gradually decreased with the increase of cardiac function classification (P<0.05); Pearson results showed that the serum NAMPT level in patients with chronic heart failure was positively correlated with LVEDD and BNP levels (r=0.750, 0.757, P<0.05), and negatively correlated with LVEF level (r=-0.759, P<0.05); serum mir-206 level was negatively correlated with LVEDD and BNP levels (r=-0.775, -0.883, P<0.05), and positively correlated with LVEF level (r=0.819, P<0.05); ROC results showed that the area under the curve (AUC) of serum NAMPT and mir-206 levels predicting chronic heart failure was 0.853 (95% CI: 0.773-0.913) and 0.981 (95% CI: 0.935-0.998), respectively, the corresponding specificity was 61.76% and 97.06%, respectively, the sensitivity was 93.42% and 88.16%, respectively, the AUC of the combination of serum NAMPT and mir-206 predicting chronic heart failure was 0.993, with a specificity of 97.06%, and a sensitivity of 96.05%.Conclusion: The expression level of serum NAMPT in patients with chronic heart failure increases, and the expression level of mir-206 decreases. They are related to the patient's heart function classification, have certain predictive values for the occurrence of chronic heart failure and are expected to become biological indicators for the diagnosis of chronic heart failure.
|
|
|
|
|
|
[1] 王志燕,陈晨,吕强,等.2021年ESC急慢性心力衰竭诊断与治疗指南解读[J].中华心血管病杂志,2021,49(12):1252~1255.
[2] 姚璐,武云涛,田国祥.托伐普坦在老年心力衰竭患者中的应用评价[J].中国循证心血管医学杂志,2019,11(2):252~253,256.
[3] Horodinschi RN,Bratu OG,Dediu GN,et al.Heart failure and chronic obstructive pulmonary disease:a review[J].Acta Cardiol,2020,75(2):97~104.
[4] Huang Y,Peng Y,Sun J,et al.Nicotinamide phosphoribosyl transferase controls NLRP3 inflammasome activity through MAPK and NF-κB signaling in nucleus pulposus cells,as suppressed by melatonin[J].Inflammation,2020,43(3):796~809.
[5] Cao HL,Liu ZJ,Huang PL,et al.lncRNA-RMRP promotes proliferation,migration and invasion of bladder cancer via miR-206[J].Eur Rev Med Pharmacol Sci,2019,23(3):1012~1021.
[6] 中华医学会心血管病学分会心力衰竭学组,中国医师协会心力衰竭专业委员会,中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2018[J].中华心力衰竭和心肌病杂志,2018,2(4):196~225.
[7] Sciomer S,Moscucci F,Salvioni E,et al.Role of gender,age and BMI in prognosis of heart failure[J].Eur Prev Cardiol,2020,27(2):46~51.
[8] 李杨杨,胡芳芳,李莉.呼吸机相关性肺炎患者血清降钙素原,载脂蛋白E和烟酰胺磷酸核糖转移酶表达及其预后相关影响因素分析[J].临床误诊误治,2019,291(11):72~76.
[9] 苟小霞,阮培刚,徐颖,等.基于数据挖掘分析nampt在脑胶质瘤中的表达及意义[J].肿瘤预防与治疗,2019,32(3):221~227.
[10] Qin L,Liu X,Li Y.Correlation of serum BNP and ET-1 levels with cardiac pump function and ventricular remodeling in patients with heart failure[J].Cell Mol Biol (Noisy-le-grand),2020,66(3):125~131.
[11] Hu W,Feng H,Xu X,et al.Long noncoding RNA FOXD2-AS1 aggravates hepatocellular carcinoma tumorigenesis by regulating the miR-206/MAP3K1 axis[J].Cancer Med,2020,9(15):5620~5631.
[12] 郭登斌,王春,刘清平.miR-1、miR-206与IGF-1在骨折延迟愈合患者血清中的表达关系及意义[J].广东医学,2019,40(10):1487~1491.
[13] 白爱红,付秀虹,李荣香,等.多囊卵巢综合征患者血清miR-206和IGF-1的表达水平及临床意义[J].中国妇幼保健,2019,34(1):139~142. |
|
|
|
2022, Vol. 28 
