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| Effect of Laparoscopic Hepatectomy on Immunoglobulin and VEGF and AFGF Levels in Patients with Primary Liver Cancer |
| CHEN Jiaxin, HU Song,CHEN Yifa, et al |
| Ezhou Central Hospital, Hubei Ezhou 436001, China |
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Abstract Objective: To analyze the effects of laparoscopic hepatectomy on the levels of immunoglobulin, VEGF and aFGF in patients with primary liver cancer. Methods:A retrospective analysis was performed on 80 patients with primary liver cancer admitted to our hospital from September 2019 to September 2020, who were divided into observation group and control group according to surgical methods. In the observation group, 45 patients underwent laparoscopic hepatectomy and 35 patients in the control group underwent traditional open hepatectomy. The two groups were compared in terms of perioperative conditions, immune function indexes, vascular endothelial growth factor (VEGF) and acidic fibroblast growth factor (aFGF) levels and liver function indexes after surgery.Results: There was no statistically significant difference in the duration of surgery in the observation group compared with the control group (P>0.05); intraoperative blood loss was significantly less in the observation group compared with the control group (P<0.05); the time to first anal discharge and the total hospital stay were shorter in the observation group compared with the control group (P<0.05); immunoglobulin M (IgM), immunoglobulin A (IgA) and immunoglobulin G (IgG) levels were significantly higher in the observation group compared to the control group (P<0.05); VEGF and aFGF levels were significantly lower in the observation group compared to the control group (P<0.05); total bilirubin (TBil), alanine transaminase (ALT) and glutathione transaminase (AST) levels were significantly lower in the observation group compared to the control group after surgery (P<0.05).Conclusion: Compared with patients receiving traditional open hepatectomy, laparoscopic hepatectomy can improve perioperative conditions and reduce the inhibition of immune function. In addition, it can reduce the levels of VEGF and aFGF in patients and the injury of liver function caused by surgery.
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2022, Vol. 28 
