顺铂腹腔热灌注联合静脉化疗治疗胃癌疗效及对血清IGF-1 VEGF EGFR水平的影响

doi:10.3969/j.issn.1006-6233.2022.03.021

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Abstract Objective: To investigate the curative effect of cisplatin hyperthermic intraperitoneal chemotherapy (HIPEC) combined with intravenous chemotherapy in the treatment of gastric cancer, and its influence on serum insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) levels. Methods: Totally 112 patients with gastric cancer were divided into observation group (n=60) and control group (n=52) according to the principle of voluntariness. The observation group was given cisplatin HIPEC combined with intravenous chemotherapy, while the control group was given intravenous chemotherapy alone. The short-term curative effect, quality of life and adverse reactions were compared between the two groups. The levels of serum IGF-1, VEGF and EGFR were determined before and after treatment. Results: The short-term total response rate in the observation group was 61.67%, which was significantly higher than the control group at 36.54%(P<0.05). The incidence of nausea, vomiting and bone marrow suppression in the observation group was slightly higher than that in the control group, with statistical differences (P<0.05). After treatment, serum IGF-1, VEGF and EGFR levels were significantly reduced in the two groups, and the difference of each index in the observation group was greater than that in the control group. (P<0.05). Conclusion: Cisplatin HIPEC in combination with intravenous chemotherapy can achieve better short-term curative effect than intravenous chemotherapy alone in the treatment of gastric cancer. The former can significantly improve serum IGF-1, VEGF and EGFR levels of patients without increasing side effects.

Key words： Gastric cancer Cisplatin Hyperthermic intraperitoneal chemotherapy Intravenous chemotherapy Insulin-like growth factor-1 Vascular endothelial growth factor Epidermal growth factor receptor

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.03.021 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I3/451

[1] 郑荣寿,孙可欣,张思维,等.2015年中国恶性肿瘤流行情况分析[J].中华肿瘤杂志,2019,41(1):19~28.
[2] Cainap C,Vlad C,Seicean A,et al.Gastric cancer:adjuvant chemotherapy versus chemoradiation.A clinical point of view[J].BUON,2019,24(6):2209~2219.
[3] Zhu L,Xu Y,Shan Y,et al.Intraperitoneal perfusion chemotherapy and whole abdominal hyperthermia using external radiofrequency following radical D2 resection for treatment of advanced gastric cancer[J].Int Hyperthermia,2019,36(1):403~407.
[4] 方瑜,王琳,李桂梅,等.c-Met、VEGF、EGFR和HER-2在AFP阳性胃癌中的表达研究[J].中国癌症杂志,2016,26(8):662~669.
[5] Gong Y,Pan S,Wang X,et al.A novel lymph node staging system for gastric cancer including modified Union for cancer Control/American Joint Committee on cancer and Japanese Gastric Cancer Association criteria[J].Eur Surg Oncol,2020,46(10):27~32.
[6] 李增山,李青.2010年版消化系统肿瘤WHO分类解读[J].中华病理学杂志,2011,40(5):351~354.
[7] 苗儒林,李子禹,季加孚.从中国胃肠肿瘤外科联盟相关数据分析我国早期胃癌诊治现状和发展趋势[J].中国实用外科杂志,2019,39(5):419~423.
[8] van den Ende T,Ter Veer E,Machiels M,et al.The Efficacy and Safety of (Neo)Adjuvant Therapy for Gastric Cancer:A Network Meta-analysis[J].Cancers (Basel),2019,11(1):80.
[9] 姬忠贺,于洋,刘刚,等.肿瘤细胞减灭术加腹腔热灌注化疗治疗胃癌腹膜转移的预后列线图构建与验证[J].中华普通外科杂志,2019,34(10):833~836.
[10] Blum Murphy M,Ikoma N,Wang X,et al.Phase I trial of hyperthermic intraperitoneal chemoperfusion (HIPEC) with cisplatin,mitomycin,and paclitaxel in patients with gastric adenocarcinoma and associated carcinomatosis or positive cytology[J].Ann Surg Oncol,2020,27(8):2806~2811.
[11] Ba MC,Long H,Zhang XL,et al.Laparoscopic hyperthermic intraperitoneal perfusion chemotherapy for patients with malignant ascites secondary to unresectable gastric cancer[J].Surg Laparosc Endosc Percutan Tech,2020,30(1):55~61.
[12] 张群,朱武,郑佳,等.胃癌患者腹腔热灌注联合全身静脉化疗的临床效果及对免疫功能的影响[J].中国肿瘤临床与康复,2019,26(11):1196~1199.
[13] Han H,Lim JW,Kim H.Lycopene inhibits activation of epidermal growth factor receptor and expression of cyclooxygenase-2 in gastric cancer cells[J].Nutrients,2019,11(9):2113~2113.
[14] 杨俊娥,李玲玲,石庆芳,等.乙醛脱氢酶1A1和表皮生长因子受体在胃癌中的表达及临床意义[J].中国临床药理学杂志,2020,36(5):499~502.