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Correlation Between Dynamic Changes of Serum PTX3 and Neuroprotection After Remote Ischemia in Patients with Acute Cerebral Infarction |
YAO Xiaomeng, et al |
The Affiliated Central Hospital of Shenyang Medical College, Liaoning Shenyang 110024,China |
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Abstract Objective: To study the correlation between dynamic changes of serum pentraxin 3 (PTX3) and neuroprotection after remote ischemia in patients with acute cerebral infarction (ACI). Methods: A total of 150 patients with ACI treated in the hospital between June 2019 and June 2021 were enrolled and divided into experimental group and control group by simple random grouping method, 75 cases in each group. The control group was given standardized treatment, while the experimental group was given ischemic preconditioning treatment on the basis of the control group. The level of serum PTX3 was compared between the two groups. The nerve function was assessed by NIHSS score, and its correlation with serum PTX3 was analyzed. At 90d after treatment, short-term prognosis was assessed by mRS score and BartheI index. The prognosis between the two groups was compared. The correlation between serum PTX3 and prognosis and its predictive value for prognosis were analyzed. Results: After treatment, level of serum PTX3 and NIHSS score in both groups were significantly decreased, which were lower in experimental group than in control group at 7d and 14d after treatment (P<0.05). After treatment, the experimental group had significantly lower mRS scores, and higher BartheI index than the control group. The changes were greater in the experimental group than in the control group (P<0.05). The level of serum PTX3 was positively correlated with NIHSS and mRS scores, while negatively correlated with BartheI index (P<0.05). The area under the ROC curve (AUC), sensitivity, and specificity of serum PTX3>3.34μg/L to predict the prognosis of patients with ACI were 0.948, 92.86%, and 82.26% (P<0.05). Conclusion: The level of serum PTX3 is significantly correlated with neurological deficits and prognosis in ACI patients, which can be applied to assessing neurological deficits and predict short-term prognosis in ACI patients after RIC.
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[1] 范磊,岳秉宏,刘星亮,等.急性脑梗死患者血清胎球蛋白A水平与颈动脉易损斑块的关系研究[J].现代预防医学,2019,46(7):1339~1344. [2] 中国中西医结合学会神经科专业委员会.中国脑梗死中西医结合诊治指南(2017)[J].中国中西医结合杂志,2018,38(2):136~144. [3] 李海霞,郭倩,沈月贞,等.远隔缺血后适应对老年急性脑梗死患者预后的影响[J].中华老年医学杂志,2018,37(11):1218~1222. [4] 王心颖,丁文婷,鲍双振,等.远隔缺血后适应治疗对缺血性脑卒中患者神经功能保护作用的临床研究[J].中国全科医学,2018,21(18):28~31. [5] Vinciguerra A,Cepparulo P,Anzilotti S,et al.Remote postconditioning ameliorates stroke damage by preventing let-7a and miR-143 up-regulation[J].Theranostics,2020,10(26):12174~12188. [6] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中华神经科杂志,2010,43(2):146~153. [7] 张子英,王新华,席妹景,等.外周血miR-25表达与急性脑梗死患者凋亡分子含量及90天预后的相关性[J].中国动脉硬化杂志,2020,28(9):42~46. [8] 王德征,薛晓丹,张辉,等.天津市1999至2015年脑梗死死亡率变化趋势分析[J].中华心血管病杂志,2018,46(2):152~158. [9] 王国峰,刘伯芹,官明德.肢体远隔缺血后适应通过磷脂酰肌醇3激酶/Akt通路保护大鼠局灶性脑缺血再灌注损伤[J].国际脑血管病杂志,2018,26(8):605~610. [10] 韩雪,高燕军,赵士娇.血清正五聚蛋白3、超敏C反应蛋白水平与急性脑梗死患者的病情严重程度及预后的关系[J].卒中与神经疾病,2019,26(1):24~28. [11] Rajkovic I,Wong R,Lemarchand E,et al.Pentraxin 3 promotes long-term cerebral blood flow recovery,angiogenesis,and neuronal survival after stroke[J].Mol Med (Berl),2018,96(12):1319~1332. [12] 吴剑,谷亚坤,刘佳.缺血/缺氧预适应的神经保护作用研究进展[J].首都医科大学学报,2020,41(4):664~670. |
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