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| Effect of Piracetam Combined with Shuxuening Injection on Hemorheology and Levels of Serum Hcy and Hs-CRP in Patients with Hypertension Complicated with Cerebral Infarction |
| JIANG Xue, JIANG Haiyan |
| West China Guang'an Hospital of Sichuan University, Sichuan Guang'an 638000, China |
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Abstract Objective: To investigate the effect of piracetam combined with Shuxuening injection on hemorheology and levels of serum homocysteine (Hcy) and high-sensitivity C-reactive protein (hs-CRP) in patients with hypertension complicated with cerebral infarction. Methods: A total of 86 patients with hypertension and cerebral infarction admitted to the hospital between January 2019 and October 2020 were selected and divided into combined group (n=43) and regular group (n=43) by simple random grouping. Patients in regular group were treated with piracetam, and patients in combined group were given piracetam combined with Shuxuening injection. The neurological function [National Institutes of Health Stroke Scale (NIHSS)], cognitive function [Mini-Mental State Examination(MMSE)], carotid artery ultrasound indicators [carotid artery intima-media thickness (IMI), carotid artery plaque area, carotid artery blood flow], hemorheology (plasma viscosity, high-shear whole blood viscosity, low-shear whole blood viscosity, hematocrit) and levels of serum Hcy, hs-CRP, neuron-specific enolase (NSE), myelin basic protein (MBP) and central nervous system specific protein (S100β) were observed in the two groups before and after treatment. Results: After 3 months of treatment, the NIHSS score of the two groups was lower than that before treatment while the MMSE score was higher than that before treatment (P<0.05), IMI and carotid artery plaque area were smaller than those before treatment, carotid artery blood flow was more than that before treatment (P<0.05), and the improvement status of the above indicators in combined group were better than those in regular group (P<0.05). After 3 months of treatment, the high-shear whole blood viscosity, low-shear whole blood viscosity, plasma viscosity, hematocrit and levels of serum Hcy, hs-CRP, NSE, MBP and S100β in the two groups were decreased compared with those before treatment, and the difference of each index before and after treatment in combined group were significantly higher than those in regular group (P<0.05). Conclusion: Piracetam combined with Shuxuening injection in the treatment of hypertension with cerebral infarction can effectively improve the neurological function and cognitive function, inhibit the atherosclerotic plaque formation and reduce blood viscosity and inflammation level, and it is beneficial to the outcomes of disease.
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2022, Vol. 28 
