丁苯酞联合阿司匹林和硫酸氢氯吡格雷对急性脑梗死患者NIHSS评分和mRS评分影响

doi:10.3969/j.issn.1006-6233.2022.02.031

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Abstract Objective: To study the effect of drugs on NIHSS score and mRS Score in patients with acute cerebral infarction. Methods: A total of 86 cases with acute cerebral infarction who were treated from August 2018 to June 2020 were selected as research subjects and divided into observation group (43 cases) and control group (43 cases) by simple random grouping.The control group was treated with aspirin and clopidogrel bisulfate. The clinical efficacy, NIHSS score, mRS score and changes in the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hs-CRP) before and after treatment were compared between the two groups. Results: The total effective rate of the observation group after treatment was significantly higher than that of the control group (93.02%VS72.09%) (χ²=6.541, P=0.011); the NIHSS and mRS scores of the two groups of patients after treatment were decreased (P<0.05), and the difference of NIHSS and mRS scores before and after treatment in the observation group was significantly higher than that in the control group (P<0.05); after treatment, the levels of TNF-α, IL-6 and hs-CRP in the two groups were lower than those before the treatment (P<0.05), and the difference of TNF-α, IL-6 and hs-CRP index levels in the observation group before and after treatment was significantly higher than that in the control group(P<0.05). Conclusion: The clinical effect of butylphthalide combined with aspirin and clopidogrel bisulfate in patients with acute cerebral infarction is better, which can effectively reduce the level of inflammation and promote the recovery of nerve function.

Key words： Acute cerebral infarction Butyl phthalide Aspirin Clopidogrel bisulfate NIHSS score MRS score

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	WU Peipei
	DONG Shaojun
	SUN Tiantian
	et al

Cite this article:

WU Peipei,DONG Shaojun,SUN Tiantian, et al. Effect of Butylphthalide Combined with Aspirin and Clopidogrel Sulfate on NIHSS Score and MRS Score in Patients with Acute Cerebral Infarction[J]. HeBei Med, 2022, 28(2): 327-331.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.02.031 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I2/327

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