超声引导下腰骶神经丛阻滞联合吸入麻醉对全髋关节置换术患者氧化应激 免疫功能及认知功能的影响

doi:10.3969/j.issn.1006-6233.2022.02.020

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Abstract Objective: To investigate the effects of ultrasound-guided lumbosacral plexus block combined with inhalation anesthesia on oxidative stress, immune function and cognitive function in patients with total hip arthroplasty. Methods: 120 patients undergoing total hip arthroplasty in our hospital from December 2018 to December 2020 were selected. According to the random number table, they were divided into control group and study group, 60 cases in each. The patients in the control group were treated with inhalation anesthesia, and the patients in the study group were treated with ultrasound-guided lumbosacral plexus block combined with inhalation anesthesia, to compare the data of oxidative stress, immune function and cognitive function between the two groups before operation and 1d, 3d after operation. Results: There was no significant difference in SOD,MDA,CD3⁺,CD4⁺,CD8⁺,NK level and MMSE score between the two groups before operation (P>0.05). The SOD,CD3⁺,CD4⁺,NK level and MMSE score of the study group 1 d after operation were higher than those of the control group, and the MDA, CD8⁺ level were lower than those of the control group (P>0.05). Conclusion: Ultrasonic guided lumbosacral plexus block combined with inhalation anesthesia in patients with total hip arthroplasty can effectively reduce oxidative stress response, alleviate immunosuppression and reduce cognitive impairment, which is worthy of clinical application.

Key words： Total hip replacement Ultrasound-guided lumbosacral plexus block Inhalation anesthesia Oxidative stress Immune function Cognitive function

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	DONG Biqian
	FAN Wanqiu
	GAO Qin

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DONG Biqian,FAN Wanqiu,GAO Qin. Effects of Ultrasound-Guided Lumbosacral Plexus Block Combined with Inhalation Anesthesia on Oxidative Stress, Immune Function and Cognitive Function in Patients Undergoing Total Hip Arthroplasty[J]. HeBei Med, 2022, 28(2): 277-281.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.02.020 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I2/277

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