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| The Predictive Value of Serum IL-17A and OXA for Postoperative Cognitive Dysfunction in Elderly Patients of Hip Fracture Undergoing General Anesthesia |
| CHEN Meizhu, LUO Lin, TIAN Yi |
| Haikou Affiliated Hospital of Central South University Xiangya School of Medicine/Haikou Municipal Hospiatal, Hainan Haikou 570208, China |
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Abstract Objective: To investigate the predictive value of serum interleukin-17A (IL-17A) and orexin A (OXA) for postoperative cognitive dysfunction in elderly patients of hip fracture undergoing general anesthesia and analyze the influencing factors. Methods: A total of 185 elderly patients of hip fracture undergoing general anesthesia were selected as the research subjects. According to their postoperative cognitive dysfunction, they were divided into cognitive dysfunction group (POCD group, 51 cases) and non-cognitive dysfunction group (NPOCD group, 134 cases). The serum levels of IL-17A and OXA were detected by ELISA. The receiver operating characteristic (ROC) curve were used to analyze the predicting value of serum IL-17A and OXA levels on POCD, and multivariate logistic regression analysis was used to analyze the influencing factors of POCD. Results: The levels of IL-17A and OXA in the two groups were significantly higher than those before operation (P<0.01). The level of OXA in POCD group was significantly higher than that in NPOCD group (P<0.01), while the level of OXA in POCD group was lower than that in NPOCD group (P<0.01). The ROC curve analysis showed that the cutoff values of serum IL-17A and OXA for POCD prediction were 33.96 ng/ml and 249.70 pg/ml, respectively, and AUC were 0.843 and 0.799, respectively. The logistic regression analysis showed that age, preoperative complications≥3, serum IL-17A≥33.96pg/ml, OXA≤249.70pg/ml were the influencing factors of POCD. Conclusion: Serum IL-17A and OXA levels are the influencing factors of cognitive dysfunction in elderly patients of hip fracture after general anesthesia. They are closely related to cognitive dysfunction and could be used as biomarkers for predicting POCD.
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2022, Vol. 28 
