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| Effect of Different Doses of Propofol on Emergence Agitation, Sedative Effect and Vital Signs of Children After Sevoflurane Anesthesia |
| ZHAO Jianghe, WU Xiaole, LI Li, et al |
| Xuzhou Children's Hospital, Xuzhou Medical University, Jiangsu Xuzhou 221000, China |
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Abstract Objective: To investigate the effect of different doses of propofol on emergence agitation, sedative effect and vital signs of children after sevoflurane anesthesia. Methods: Totally 173 children who underwent elective tonsillectomy in the hospital between February 2018 and July 2020 were randomly divided into group A (n=55), group B (n=60) and group C (n=58). All were given general anesthesia with sevoflurane. Children in group A were injected intravenously with 0.10ml/kg of 0.90% sodium chloride injection, while children in group B and group C were injected intravenously with 1.00mg/kg and 2.00 mg/kg of propofol, respectively. Postoperative recovery and changes in vital signs before induction of anesthesia (T0), immediately after operation (T1), at extubation (T2), 5min after extubation (T3) and 10min after extubation (T4) were observed. The Pediatric Anesthesia Emergence Delirium Scale (PAED) scores, Ramasay sedation scores (RSS) and the Face, Legs, Activity, Cry and Consolability (FLACC) scores at T2~T4 were recorded. Adverse reactions were observed. Results: The length of PACU stay of group C was significantly shorter than that of the other two groups (P<0.05); there were no significant differences in other indicators (P>0.05). Compared with T0, HR and MAP of group A and group B increased significantly at T, T2 and T3. HR and MAP of group C increased significantly at T1 and T2 (P<0.05). Compared with group A and group B, HR and MAP of group C were significantly lower at T1, T2 and T3 (P<0.05). Compared with T2, the PAED scores and FLACC scores of the three groups decreased significantly, and the RSS scores increased at T3 and T4 (P<0.05). The PAED scores and FLACC scores of group C at T2, T3 and T4 were significantly lower than those of group A and group B, and the RSS scoreswere significantly higher than those of group A and group B (P<0.05). No adverse reactions such as vomiting, spasm, hypoxia and asphyxia were observed in the three groups after operation. Conclusion: Intravenous injection of 2.00 mg/kg of propofol after operation can effectively prevent postoperative emergence of agitation and maintain stable vital signs of the children, with obvious sedative and analgesic effects and high safety.
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2022, Vol. 28 
