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| Relationship Between Expression Level of Serum Calcium-Binding Protein Complex S100A8/A9 and Unstablecarotid Artery Plaques in Elderly Patients with Hypertension |
| LI Hanming, LIU Yuhua, FANG Runquan, et al |
| Dongguan People's Hospital, Guangdong Dongguan 523000, China |
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Abstract Objective: To explore the relationship between expression level of serum calcium-binding protein complex S100A8/A9 and unstablecarotid artery plaques in elderly patients with hypertension. Methods: The clinical data of 152 elderly patients with hypertension admitted to the hospital between April 2018 and April 2021 were retrospectively analyzed. The patients were grouped according to whether the carotid artery plaque was stable or not, including stable group (n=61) and unstable group (n=91). The levels of serum S100A8/A9, blood uric acid (UA), fasting plasma glucose (FPG) and blood lipids [triacylglycerol (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL)] and intima-media thickness (IMT) of common carotid artery and internal carotid artery were compared between the two groups. Pearson correlation analysis was used to explore the relationship between serum S100A8/A9 and other clinical indicators in patients with different plaque properties. Results: There was no statistical difference in TG level between the two groups (P>0.05). The levels of serum S100A8/A9, UA, FPG, HDL and LDL and IMT values of common carotid artery and internal carotid artery in unstable group were higher than those in stable group (all P<0.05). According to Pearson correlation analysis, there was no statistical significance in the correlation between serum S100A8/A9 and levels of FPG and TG in patients with different plaque properties, and there was also no statistical significance in the correlation between serum S100A8/A9 and LDL and internal carotid artery IMT of patients in stable group (all P>0.05). Serum S100A8/A9 of patients in unstable group was positively correlated with UA, HDL, LDL, common carotid artery IMT and internal carotid artery IMT, and serum S100A8/A9 in stable group was positively correlated with UA, HDL and common carotid artery IMT (all P<0.05). Conclusion: The formation of unstable carotid artery plaques in elderly patients with hypertension may be related to the levels of serum S100A8/A9, UA, FPG, HDL and LDL.
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2022, Vol. 28 
