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| Effects of Different Administration Methods of Oxycodone on the Level of Pain-Causing Substances and Bladder Spasm Pain in Patients After TURP |
| ZHOU Xuehui, SHAO Guoli, PENG Liyan, et al |
| Zhujiang Hospital, Southern Medical University, Guangdong Guangzhou 510000, China |
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Abstract Objective: To explore the effects of different administration methods of oxycodone on the level of pain-causing substances and bladder spasm pain in patients after transurethral resection of prostate (TURP). Methods: Researchers retrospectively analyzed the clinical data of 116 TURP patients admitted to our hospital from March 2020 to March 2021, and divided them into groups A, B, and C according to their different administration methods. 45 patients in group A adopting patient self-control intravenous analgesia (patient controlled intravenous analgesia, PCIA) were continuously pumped. 37 patients in group B received a single PCIA administration, and 34 patients in group C did not take PCIA analgesia. The levels of postoperative pain-causing substances (plasma substance P, 5-hydroxytryptamine (5-HT)), the number of bladder cramps at 48 hours, the visual analogue scale (VAS), and the occurrence of adverse reactions were compared among different groups of patients. Results: VAS scores, 48h bladder spasms and total duration of patients in groups A and B were significantly lower than those of group C. There were statistically significant differences in VAS scores, 48h bladder spasms and total duration between the three groups, P<0.05; The levels of substance P and 5-HT in groups A and B were significantly lower than those in group C. The differences in the levels of substance P and 5-HT in the three groups were statistically significant, P<0.05; Group A (35.56%), B (32.43) %) and C (20.59%) had no statistically significant difference in the total incidence of adverse reactions between patients, P>0.05. Conclusion: Both continuous pump injection and single administration of oxycodone PCIA can achieve analgesia and relieve bladder spasm after TURP, and there is no serious adverse reaction, which is worthy of clinical reference.
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2022, Vol. 28 
