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| Effect of Continuous Bedside Hemofiltration on Serum Lipoprotein (a) Cholinesterase Activity and Cardiac Function Indexes in Patients with Acute Organophosphorus Pesticide Poisoning |
| BAI Yanli, LI Yan, YUAN Lingling, et al |
| The People's Hospital of Inner Mongolia Autonomous Region, Inner Mongolia Hohhot 010086, China |
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Abstract Objective: To explore the effect of continuous bedside hemofiltration on serum lipoprotein (a) [Lp (a)], cholinesterase (ChE) activity and cardiac function indexes in patients with acute organophosphorus pesticide poisoning (AOPP). Methods: A total of 160 patients with AOPP admitted to the hospital from May 2016 to May 2020 were selected and randomly divided into observation group (n=86) and control group (n=74). The control group received conventional symptomatic treatment, and on this basis, the observation group received continuous bedside hemofiltration. The clinical effects, changes in serum Lp(a) level, ChE activity and cardiac function indexes at different time points were compared between the two groups. Results: The coma duration, mechanical ventilation time/hospital stay and serum ChE activity recovery time of the observation group were shorter than those of the control group. The dosage of atropine was lower than that in the control group, and the mortality rate was lower than that in the control group (P<0.05). After treatment, serum Lp(a), ChE activity and cardiac function indexes in the two groups changed over time to varying degrees. 24h, 48h and 72h after treatment, the observation group had lower serum Lp(a) levels and higher left ventricular ejection fraction (LVEF) than the control group (P<0.05). 48h and 72h after treatment, serum ChE activity in the observation group was higher than that in the control group, and the left ventricular end systolic diameter (LVIDs) and B-type natriuretic peptide (BNP) levels were lower than those in the control group (P<0.05). 24h after treatment, there were no significant differences in serum ChE activity, LVIDs and BNP levels between the two groups (P>0.05). Conclusion: Continuous bedside hemofiltration is effective in the treatment of AOPP. It can effectively improve the patients' serum Lp(a) level and ChE activity, reduce myocardial damage and promote cardiac function recovery.
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2022, Vol. 28 
