血清PA ChE和TBA水平与肝硬化门静脉高压伴上消化道出血的关系

doi:10.3969/j.issn.1006-6233.2022.01.010

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Abstract Objective: To investigate the relationship of serum prealbumin (PA), cholinesterase (ChE) and total bile acid (TBA) levels with cirrhotic portal hypertension complicated by upper gastrointestinal bleeding. Methods: A total of 273 patients with cirrhotic portal hypertension and upper gastrointestinal bleeding (cirrhosis bleeding group) were selected between January 2019 and April 2021, including 58 patients with grade A liver function, 119 patients with grade B liver function, and 96 patients with grade C liver function. Meanwhile, 82 patients with upper gastrointestinal bleeding caused by gastroduodenal ulcer and without history of liver cirrhosis were selected as the non-cirrhosis bleeding group, and 65 healthy volunteers without history of liver cirrhosis were selected as the healthy control group. Serum PA, ChE and TBA levels in the 3 groups were compared. The correlation of serum PA, ChE and TBA levels with liver function classification was analyzed. Results: Serum PA and ChE levels in the cirrhosis bleeding group were lower than those in the non-cirrhosis bleeding group and the healthy control group (P<0.05), while serum TBA levels were higher than those in the non-cirrhosis bleeding group and the healthy control group (P<0.05). Serum PA and ChE levels of patients with grade C liver function were lower than those of patients with grade B and grade A (P<0.05), while serum TBA levels were higher than those of patients with grade B and grade A (P<0.05). Serum PA and ChE levels were negatively correlated with the grade of liver function (rs=-0.553, rs=-0.439, P<0.05), while serum TBA level was positively correlated with the grade of liver function (rs=0.628, P<0.05). Conclusion: Patients with cirrhotic portal hypertension and upper gastrointestinal bleeding have low serum PA and ChE levels, and high serum TBA level. Serum PA, ChE and TBA are closely related to liver function classification of the patients.

Key words： Liver cirrhosis Portal hypertension Upper gastrointestinal bleeding Prealbumin Cholinesterase Total bile acid

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.01.010 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I1/47

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