健脾益肾壮骨汤治疗原发性骨质疏松症的疗效及对血清IGF-1 MMP-9 ET-1水平的影响

doi:10.3969/j.issn.1006-6233.2021.12.036

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Abstract Objective: To investigate the therapeutic effect of Jianpi Yishen Zhuanggu Decoction on primary osteoporosis. Methods: 200 patients with primary osteoporosis admitted to our hospital from March 2017 to March 2020 were selected as the research subjects and randomly divided into a control group (n=100) and an observation group (n=100); the control group was administered vitamin D calcium chewable tablets (0.6g / time, 1 time / day) and calcitriol capsules (0.25μg / time, 3 times / day), the observation group was administered Jianpi Yishen Zhuanggu Decoction (1 dose per day) on the basis of the control group. The total effective rate, TCM symptom score, pain visual analogue scale (VAS), lumbar bone mineral density (BMD), biochemical indicators of bone turnover [PINP,β-CTX] and serum levels of insulin-like growth factor-1 (IGF-1), matrix metalloproteinase-9 (MMP-9) and endothelin-1 (ET-1) were compared between the two groups. Adverse reactions were observed. Results: The total effective rate of the observation group was higher than that of the control group (94.00% vs 82.00%) (P<0.05). After 6 months of treatment, the TCM symptom score, VAS score, PINP and β-CTX levels in the observation group were lower than those in the control group (P<0.0 ). The serum IGF-1 in the observation group was higher than that in the control group, and MMP-9 and ET-1 levels were lower than those in the control group (P<0.05). Conclusion: Jianpi Yishen Zhuanggu Decoction has a significant effect on primary osteoporosis, effectively alleviating symptoms, increasing bone density, and improving bone metabolism. The mechanism may be related to the up-regulation of IGF-1 and down-regulation of MMP-9. ET-1 expression is related.

Key words： Osteoporosis Jianpi Yishen Zhuanggu Bone metabolism Insulin-like growth factor-1 Matrix metalloproteinase Endothelin

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WEI Haiying,et al. Effect of Jianpi Yishen Zhuanggu Decoction on Primary Osteoporosis and Its Influence on Serum IGF-1 MMP-9 and ET-1[J]. HeBei Med, 2021, 27(12): 2101-2104.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.12.036 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I12/2101

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