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| Effect of Continuous and Intermittent Blood Purification on Renal Hemodynamics and Glucose Metabolism Indicators in Patients with Acute Kidney Injury Caused by Septic Shock |
| ZHAO Min, LI Jiming, YANG Yuying, et al |
| The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Urumqi 830000, China |
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Abstract Objective: To explore the therapeutic effects of continuous renal replacement therapy (CRRT) and intermittent hemodialysis (IHD) on patients with acute kidney injury (AKI) caused by septic shock, and their influence on renal hemodynamics and glucose metabolism indicators. Methods: 147 patients with AKI caused by septic shock treated in the hospital between March 2019 and March 2021 were selected as the research subjects, and were randomly divided into observation group (n=72) and control group (n=75). On the basis of conventional treatment, patients in the observation group were treated with CRRT and patients in the control group were treated with IHD. The relevant parameters were compared between the two groups before and after treatment. Results: The length of ICU stay, urine volume, recovery time, and organ support time of the observation group were shorter than those of the control group (P<0.05). 1 week after treatment, the levels of serum C-reactive protein (CRP) and serum creatinine (Scr) in the observation group were lower than those in the control group (P<0.05). The peak intensity (PI), mean transit time (MTT), and area under the curve (AUC) were higher or longer than those in the control group (P<0.05). The fasting blood glucose (FBG) and 2 hours postprandial blood glucose (2PBG) were lower than those in the control group (P<0.05). The different values of above indicators before and after treatment in the observation group were greater than those in the control group. Conclusion: CRRT can significantly improve inflammation, renal hemodynamics and glucose metabolism in patients with AKI caused by septic shock, and shorten the patients' recovery time.
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2021, Vol. 27 
