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The Clinical Significance of the Detection of Peripheral Blood CD64 Index and Serum Amyloid A in the Diagnosis of Bacterial Infection in Preschool Children |
QU Xiaowei, et al |
The Affiliated Hospital of Yan'an University, Shaanxi Yan'an 716000, China |
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Abstract Objective: To study the clinical significance of peripheral blood CD64 index and serum amyloid A (SAA) detection in the diagnosis of bacterial infections in preschool children. Methods: With the retrospective analysis method, 200 preschool children with infectious diseases admitted from January 2018 to January 2020 were selected as the research subjects. According to different pathogens, they were divided into children with viral infections (virus group, n=100) and children with bacterial infections(bacterial group, n=100); at the same time, healthy children who were admitted to the hospital for physical examination during the same period were selected as the research subjects as the healthy group (n=100). Comparison was conducted on the CD64 index, SAA level and positive rate of the three groups of subjects, the CD64 index and SAA level before and after antibiotic treatment in the bacterial group, and the efficacy of CD64 and SAA in the diagnosis of bacterial infections was analyzed. Results: The CD64 index and SAA level of the bacterial group were significantly higher, and the difference was significant (P<0.05); compared with the healthy group, the SAA level of the virus group was significantly higher, and the difference was significant (P<0.05) . The CD64 index and SAA levels of children in the bacterial group were significantly lower than those before treatment, and the difference was significant (P<0.05). Compared with the virus group and the healthy group, the bacterial group had a significantly higher CD64 index and SAA positive rate, and the difference was significant (P<0.016); compared with the healthy group, the virus group had a significantly higher SAA positive rate, and the difference was significant (P<0.016). The specificity and positive predictive value of CD64 index in the diagnosis of bacterial infection were significantly higher than SAA, and the difference was significant (P<0.05). Conclusion: CD64 index and SAA test have important clinical value in the diagnosis and evaluation of bacterial infection in preschool children, and CD64 index is more valuable in the diagnosis.
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