哮喘患儿血清Eotaxin水平与肺功能 Eos及sIgE的关系分析

doi:10.3969/j.issn.1006-6233.2021.11.023

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Abstract Objective: To explore the relationship between serum Eotaxin level and lung function, Eos and sIgE in children with asthma. Methods: A retrospective analysis of the basic data of 65 healthy subjects (control group) and 67 children with asthma (observation group) collected from February 2018 to September 2020 were all tested for lung function, Eotaxin, Eos, and sIgE. The above indicators between the two groups of children were compared, and Pearson's method was conducted to analyze the correlation between Eotaxin and Eos, sIgE, and lung function. Results: PEF, FEV1 and FVC in the observation group were lower than those in the control group, while Eotaxin, Eos and sIgE were higher than those in the control group (P<0.05). According to Pearson method, Eotaxin is positively correlated with Eos and sIgE; it is negatively correlated with PEF, FEVI, and FVC. Multiple stepwise regression analysis showed that Eos, sIgE, and FEVI are all Eotaxin influencing factors, and Eotaxin=17.791+4.169×Eos+0.779×sIgE+(-5.711)×FEVI (R2=0.974). Conclusion: Eotaxin is closely related to Eos, sIgE and lung function, and participates in the pathophysiological process of children with asthma.

Key words： Asthma Eosinophil chemokine Lung function Eosinophils Relationship

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	TANG Ping
	WANG Denglian
	LIINAG Yan
	et al

Cite this article:

TANG Ping,WANG Denglian,LIINAG Yan, et al. An Analysis of the Relationship Between Serum Eotaxin Level and Lung Function Eos and SIgE in Children with Asthma[J]. HeBei Med, 2021, 27(11): 1881-1885.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.11.023 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I11/1881

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