|
|
|
| Efficacy of Enalapril Maleate Folic Acid Tablets in the Treatment of Elderly H-Type Hypertension with Acute Cerebral Infarction and Its Influence on Levels of SAA LP(a) NT-ProBNP and Hcy |
| ZENG Yuhong, XIAO Yin, CHEN Lin |
| The Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Hainan Haikou 570208, China |
|
|
|
|
Abstract Objective: To observe the efficacy of enalapril maleate folic acid tablets in the treatment of elderly H-type hypertension with acute cerebral infarction (ACI) and the influence on serum amyloid A (SAA), lysophosphatidic acid [LP(a)], N-terminal pro-B-type natriuretic peptide (NT-proBNP) and homocysteine (Hcy). Methods: Totally 153 elderly patients with H-type hypertension complicated with ACI treated in our hospital between October 2018 and October 2020 were selected as observation subjects, and they were classified into observation group (n=79) and control group (n=74) according to the random number table method. Patients in the control group were given conventional therapy, and patients in the observation group were additionally treated with enalapril maleate folic acid tablets based on the control group. The clinical efficacy of patients was compared, and the blood pressure, serum-related indexes [SAA, LP(a), NT-proBNP, Hcy], cognitive function [Mini-Mental State Examination (MMSE)], neurological function [National Institutes of Health Stroke Scale (NIHSS)] and self-care ability of daily living [Barthel Index (BI)] were observed in the two groups before treatment and 3 months after treatment. Results: The total clinical effective rate was significantly increased in observation group compared with that in control group (97.47% vs 89.19%), and the basic recovery rate was significantly higher than that in control group (P<0.05). 3 months after treatment, the blood pressure level of the two groups was obviously reduced compared to before treatment, and the reduction was more significant in observation group, and was closer to the normal level (P<0.05). The levels of SAA, LP(a), NT-proBNP and Hcy and score of NIHSS in both groups were lower than those before treatment, and the decreases in observation group were more obvious (P<0.05). The scores of AMSE and BI were risen in two groups of patientsthan those before treatment, and observation group had marked increases (P<0.05). Conclusion: Enalapril maleate folic acid tablets for elderly H-type hypertension with ACI has a significant effect in improving the blood pressure level, reducing levels of SAA, LP(a), NT-proBNP and Hcy, improving neurological function, and enhancing cognitive function and self-care ability of daily living.
|
|
|
|
|
|
[1] 宋彦丽,林杰,夏文静,等.同型半胱氨酸与高血压患者轻度认知障碍的相关性[J].中国卒中杂志,2020,15(12):76~80.
[2] 宋梅.马来酸依那普利叶酸片对H型高血压患者血清同型半胱氨酸水平及不良心血管事件的影响[J].内科急危重症杂志,2020,26(4):70~72.
[3] 王清,吴松笛,职瑾,等.马来酸依那普利叶酸片治疗伴H型高血压急性脑梗死患者临床疗效[J].神经损伤与功能重建,2019,14(3):143~144.
[4] 赵建国,高长玉,顼宝玉,等.脑梗死和脑出血中西医结合诊断标准(试行)[J].中国中西医结合杂志,2006,26(10):948~949.
[5] 郑筱庾.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002.91~99.
[6] 田慧军,刘卫卫,刘晓阳.PLRNLR水平与急性脑梗死患者神经功能缺损严重程度的关系[J].山西医药杂志,2020,49(9):1070~1073.
[7] 杨小梅,张转霞,蔡霞英.脑梗通汤辨证治疗气虚血瘀型脑梗死恢复期偏瘫的临床疗效[J].辽宁中医杂志,2019,46(2):315~317.
[8] 陈南耀,余丹.H型高血压伴急性脑梗死患者血清指标与颈动脉内膜中层厚度变化的关系研究[J].中华保健医学杂志,2019,21(2):119~121.
[9] 胡娇月,张爽,刘相城,等.急性脑梗死患者血清淀粉样蛋白A水平与脑卒中关系的Meta分析[J].海军医学杂志,2020,41(3):102~104.
[10] 毛少明,曾倩,任希莎,等.血清CysC,Hcy和Lp(a)水平升高与急性脑梗死病情严重程度的关系[J].标记免疫分析与临床,2019,26(8):1321~1324.
[11] 刘兵舰,赵丽玲.阿托伐他汀联合马来酸依那普利叶酸片治疗老年H型高血压急性脑梗死认知功能障碍的临床效果及对患者应激反应蛋白与神经元特异性烯醇化酶和S100β水平的影响[J].中国医药,2019,14(10):1474~1478.
[12] 洪训宇.马来酸依那普利叶酸片对H型高血压患者同型半胱氨酸和血栓前状态的影响[J].中国临床药理学杂志,2020,36(9):8~11. |
|
|
|
2021, Vol. 27 
