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| Correlation Analysis of HMGB1-RAGE Signaling Pathway and Pathogenesis of Preeclampsia |
| WANG Rui, WEI Li, LU Hongtao, et al |
| Zaozhuang Maternal and Child Health Hospital, Shandong Zaozhuang 277100, China |
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Abstract Objective: To investigate the correlation between high mobility group protein B1 (HMGB1) and its receptor advanced glycation end product (RAGE) signaling pathway and the pathogenesis of preeclampsia. Methods: 64 early epilepsy patients admitted between January 2019 and January 2021 were prospectively selected as the research objects and were divided into mild group (n = 34 cases) and severe group (n = 30) , according to different degrees of disease. 30 healthy pregnant women in the same period were selected as control group. Serum and placental tissue HMGB1, RAGE, nuclear transcription factors - kp65 (NF - kBp65) expression, HMGB1 in placental tissue, RAGE, NF - kp65 protein localization of immunohistochemical test were tested in all groups. The correlation between HMGB1, RAGE, NF- KBP65 and preeclampsia was analyzed. Results: The expressions of HMGB1, RAGE and NF-KBP65 in serum of severe group were significantly higher than those of mild group and control group, with statistical significance (P<0.05).Compared with control group and mild group, HMGB1, RAGE and NF-KBP65 in placental tissue of severe group were significantly higher, with statistical significance (P<0.05).Immunohistochemical test showed that the strong positive expressions of HMGB1, RAGE and NF-KBP65 in severe group were higher than those in mild group and control group (P<0.05), which was statistically significant. Serum HMGB1 and RAGE were positively correlated with NF-KBP65 in pregnant women with preeclampsia (r=0.387, P<0.05). Conclusion: HMGB1 and RAGE are highly expressed in serum and placental tissues of patients with preeclampsia, and are related to the severity of the disease. Considering that HMGB1-RAGE activated KBP65 signaling pathway is an important pathogenesis of preeclampsia, attention should be paid to it.
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2021, Vol. 27 
