|
|
|
| Effect of Nasal Septum Deflection Plastic Surgery Combined with Low-temperature Plasma Ablation on T Lymphocyte Subsets Serum IL-5 and OPN Levels in Patients with AR |
| ZHOU Li, LI Wen, GU Huaiyu |
| Suzhou Hospital Affiliated to Anhui Medical University, Anhui Suzhou 234000, China |
|
|
|
|
Abstract Objective: To explore the effect of nasal septal deflection plasty combined with low-temperature plasma ablation on T lymphocyte subsets, serum interleukin-5 (IL-5) and osteopontin (OPN) levels in patients with allergic rhinitis (AR). Methods: 90 patients with AR admitted to our hospital from January 2018 to December 2019 were prospectively selected and randomly divided into two groups by random number table. The control group (45 cases) was treated with nasal septum deviation plasty, and the observation group (45 cases) was treated with nasal septum deviation plasty combined with low temperature plasma ablation. The curative effect, postoperative complications, nasal mucosa integrity, T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+ / CD8+), serum IL-5 and OPN levels of AR patients before and after treatment were compared between the two groups. Results: The total effective rate of treatment in the observation group was 95.56%, which was higher than 82.22% in the control group. The difference was statistically significant (P<0.05). Repeated measures analysis of variance showed that time-point effects can significantly affect the changes in CD4+, CD8+, CD4+ /CD8+ levels (P<0.05), and the interaction effects between time-points and groups can significantly change the levels of CD4+, CD4+ /CD8+ (P<0.05) ), the reduction of CD4+ and CD4+/CD8+ in the observation group after treatment was greater than that before the treatment, and the difference was statistically significant (t=2.322, 2.970, all P<0.05); the effect between groups affects the levels of CD3+, CD4+, CD8+, CD4+ /CD8+ Not obvious (P>0.05). Repeated measures analysis of variance showed that time-point effects, inter-group effects, time-points, and inter-group interaction effects can significantly affect the changes in IL-5 and OPN levels (P<0.05). The decrease of IL-5 and OPN in the observation group after treatment was greater than that before treatment, and the difference was statistically significant (t=12.032, 6.301, all P<0.05). There was no significant difference in the incidence of complications between the observation group and the control group in terms of the mucosal integrity rate (P>0.05). Conclusion: The nasal septum deflection plasty combined with low-temperature plasma ablation has a significant curative effect and high safety in the treatment of AR, and can significantly improve the level of T lymphocyte subsets and reduce the serum IL-5 and OPN levels.
|
|
|
|
|
|
[1] Hussid M F,Lopes L F,Trombetta I C .Allergic rhinitis and adenotonsillar hypertrophy as risk factors for sleep apnea in adolescents[J].Journal of Adolescent Health,2020,66(2):60~61.
[2] 陈伟章,陈凯,张志雄,等.维生素D联合枸地氯雷他定及糠酸莫米松鼻喷雾剂对慢性鼻窦炎鼻内镜术后患者的治疗效果[J].贵州医科大学学报,2020,45(6):103~107.
[3] 李亚薇,任亮.鼻内镜下鼻中隔矫正术对治疗变态反应性鼻炎的临床效果观察[J].临床医药文献电子杂志,2019,6(97):20~23.
[4] 沙骥超,董震,孟粹达,等.美国变应性鼻炎诊疗指南(2015)解读[J].中华耳鼻咽喉头颈外科杂志,2015,50(8):699~703.
[5] 杨一兵.2005年至2011年中国主要城市自我报告过敏性鼻炎患病率增加[J].中华预防医学杂志,2019,53(7):691.
[6] 林小燕,李静,李勇,等.高迁移率族蛋白B1在变应性鼻炎的作用机制[J].中华临床免疫和变态反应杂志,2020,14(3):255~260.
[7] 王亚茹.IL-37对变应性鼻炎患者相关细胞因子免疫调控研究[J].分子诊断与治疗杂志,2021,13(1):99~102,106.
[8] Miles S,Schwarz T .Canine nasal septum deviation can be a normal variation and correlates with increasing skull indices[J].Veterinary Radiology & Ultrasound,2020,61(3):279~284.
[9] 熊雅红,罗利琴.鼻中隔偏曲成形术单用及联合下鼻甲低温等离子消融术对过敏性鼻炎患者预后的影响[J].临床与病理杂志,2020,40(7):1771~1777.
[10] 陈志伟,高燕,刘龙庆,等.射频消融联合鼻中隔偏曲矫正术对鼻中隔偏曲伴变应性鼻炎患者免疫功能及炎性因子的影响[J].临床和实验医学杂志,2017,16(6):583~587.
[11] 任小东,蒋晓平,陈天宾,等.鼻中隔偏曲成形术联合下鼻甲低温等离子消融术对变应性鼻炎患者血清IL-5及骨桥蛋白的影响及疗效[J].河北医学,2017,23(1):132~132. |
|
|
|
2021, Vol. 27 
