|
|
|
| Diagnostic Value of Color Doppler Ultrasound Combined with Serum Creatine Kinase and HCG in Placental Implantation |
| ZHOU Bingfeng, KAN Changli, GUO Yanwei, et al |
| Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China |
|
|
|
|
Abstract Objective: To analyze the diagnostic value of three-dimensional color Doppler flow imaging (CDFI) combined with serum creatine kinase (CK) and human chorionic gonadotropin (HCG) in prenatal placental implantation. Methods: 195 pregnant women with high risk factors of placental implantation and underwent cesarean section in the Affiliated Hospital of Chengde Medical University from 2015 to 2017 were selected as the study objects. According to the pathological diagnosis results of placenta after delivery, pregnant women were divided into placental implantation group (n = 86) and non fetal disc implantation group (n = 109). CK and HCG in serum were detected by automatic biochemical analyzer; CDFI was used to analyze the placental implantation of the two groups; the gold standard was the pathological diagnosis of placenta after delivery, and the diagnostic values of serum CK, CHG and CDFI single and combined diagnoses in prenatal placental implantation were analyzed. Results: The levels of serum CK and HCG in placenta group were higher than those in non placenta group (P<0.05). The results of CDFI showed that the rates of characteristic appearance such as fuzzy boundary between placenta and myometrium, placental parenchymal lacunar blood flow signal, placenta highly vascularized, dark area of irregular fluid property in placenta, and bladder protuberance of pregnant women in placenta implantation group were significantly higher than those in non placenta implantation group (P<0.05). The sensitivities of serum CK, CHG and CDFI single diagnoses were 46.51%, 48.84% and 67.44% respectively, and the specificities were 82.41%, 80.66% and 83.07% respectively. The sensitivity and specificity of CDF1 combined with CK and CHG were 94.85% and 87.62% respectively. Conclusions: Detection of DFI combined with serum CK and HCG can improve the sensitivity and accuracy of prenatal placental implantation diagnosis, which has the potential to become the diagnostic standard of prenatal placental implantation.
|
|
|
|
|
|
[1] 吴华臣,李丽华,刘燕君,等.彩色多普勒超声检查联合AFP、CK监测对产前胎盘植入诊断的价值研究[J].临床和试验医学杂志,2018,17(24):2673~2676.
[2] Tapia-Pizarro A.Hyperglycosylated chorionic gonadotropin as a modulating factor for embryo implantation and trophoblast invasion[J].Placenta,2017,51(1):104~105.
[3] 陈敦金,杨慧霞.胎盘植入诊治指南(2015)[J].中华产科急救电子杂志,2016,5(1):26~31.
[4] 杨松玉,舒雪梅,周海慧,等.彩色多普勒超声检查联合AFP、CK监测对产前胎盘植入诊断的价值研究[J].中国妇幼健康研究,2017,28(2):131~133.
[5] 单华英,费敬英,查艺葆,等.前置胎盘孕妇产前超声在胎盘植入诊断中的价值[J].中华全科医学,2017,15(7):1163~1165.
[6] Rekawek Patricia,Liu Lilly,Pan Stephanie,et al.The clinical utility of magnetic resonance imaging as an adjunct to ultrasound in the diagnosis of placenta accreta spectrum disorders[J].The Journal of Maternal-Fetal & Neonatal Medicine,2021,32(2):1~5.
[7] Kay L,Tokarska-Schlattner M,Quenot-Carrias B,et al.Creatine kinase in human erythrocytes:a genetic anomaly reveals presence of soluble brain-type isoform[J].Blood Cells Mol Dis,2017,64(1):33~37.
[8] 姜亦然,王美.胎盘植入患者血清CK、hCG、SFlt-1水平变化与三维超声血流参数的相关性[J].中国计划生育学杂志,2021,29(3):542~546,637
[9] 毕美娥,邵龙,陶晓静.甲胎蛋白、hCG检测联合多普勒彩超评估凶险性前置胎盘合并胎盘植入价值[J].中国计划生育学杂志,2019,27(4):501~503.
[10] 李萍,翟俊英,李宛玲.血清HCG、AFP水平联合MRI在前置胎盘植入及其分类诊断中的应用[J].中国CT和MRI杂志,2019,17(2):84~86. |
|
|
|
2021, Vol. 27 
