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| An Observation of the Therapeutic Effect of Repeated Transcranial MagneticStimulation Guided by Event-Related Potentials on Children with Autism Spectrum Disorder |
| JIAN Jie, et al |
| The Fifth Affiliated Hospital of Zhengzhou University, Henan Zhengzhou 450052, China |
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Abstract Objective: To analyze the clinical efficacy of high-low frequency repetitive transcranial magnetic stimulation (rTMS) under the guidance of event-related potential (ERP) combined with comprehensive rehabilitation training in the treatment of children with autism spectrum disorder (ASD). Methods: 60 ASD children who visited the fifth affiliated hospital of Zhengzhou University from January 2018 to February 2019 were selected and randomly divided into the experimental group (n=30) and the control group (n=30). Both the two groups received comprehensive rehabilitation treatment. On this basis, the control group were treated with conventional rTMS treatment, while the experimental group were treated with high-frequency and low-frequency rTMS treatment in the abnormal brain areas according to the guidance of ERP. The children’s autism rating scale (CARS), autistic children’s behavior checklist (ABC), and autism treatment evaluation scale (ATEC) were used to compare the efficacy of the two groups after treatment. Results: Before treatment, there were no significant differences in CARS, ABC and ATEC scores between the two groups(P>0.05). After 3 months of treatment, the CARS score of the experimental group (34.63±1.94) was significantly lower than that of the control group (35.73±1.96, P<0.05), the total score of ABC (50.10±4.55) was significantly lower than that of control group(54.53±5.43, P<0.05), and the ATEC score (53.53±4.70) was significantly lower than that of the control group (59.07±5.95, P<0.05). After 6 months of treatment, the CARS score of the experimental group (33.87±2.49) was significantly lower than that of the control group (31.50±2.05, P<0.05), the total score of ABC (50.00±5.13) was significantly lower than that of control group (40.01±4.86, P<0.05), and the ATEC score (47.00±5.08) was significantly lower than that of the control group (54.93±6.70, P<0.05). Conclusion: The rTMS treatment plan under the guidance of ERP has a more significant improvement effect in the treatment of ASD than the conventional rTMS, which can provide a certain reference for the treatment of children with ASD by rTMS.
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2021, Vol. 27 
