血清IGF-I HGF水平与脑胶质瘤术后低分割放疗患者预后的相关性研究

doi:10.3969/j.issn.1006-6233.2021.09.016

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Abstract Objective: To analyze the relationship between the expression of serum insulin-like growth factor 1 (IGF-1) and hepatocyte growth factor (HGF) and prognosis (mortality) of patients with hypofractionated radiotherapy after gliomas surgery. Methods: 53 patients with gliomas who underwent low-dose radiotherapy after operation and received surgery in our hospital from January 2016 to January 2017 were selected. And all patients received low-dose radiotherapy 3~4 weeks after operation, 1.8~2.0 Gy/time, a total of 54~60 Gy. According to the prognosis (death from illness) within 3 years after radiotherapy, the patients were divided into a poor prognosis group and a good prognosis group, investigated the general data of the two groups, tested and compared laboratory indicators, the relationship between serum IGF-1 and HGF expression and prognosis of patients was mainly analyzed. Results: All 53 patients were followed up for 3 years after radiotherapy, 25 were died of illness, and the mortality rate was 47.17%; the serum VEGF, TGF-β, IGF-1 and HGF levels in the poor prognosis patients were higher than the good group (P<0.05); The results of regression analysis showed that VEGF, TGF-β, IGF-1 and HGF were all the risk factors of poor prognosis in patients with hypofractionated radiotherapy after gliomas (OR>1, P<0.05); the ROC curve was drawn,VEGF, TGF-β, IGF-1 and HGF levels alone and in combination predicted the AUC of poor prognosis in patients with low segment radiotherapy after operation were all >0.80, the best prediction value could be obtained when the cut-off value of each index were 221.885pg/ml, 42.205ng/l, 111.080ng/ml and 898.495 μg/l; the correlation analysis showed that there was a positive correlation between serum IGF-I and HGF level in patients with low segment radiotherapy after gliomas (r>0, P<0.05). Conclusion: The overexpression of serum IGF-I and HGF before hypofractionated radiotherapy is associated with poor prognosis after radiotherapy in patients with glioma after operation.

Key words： Gliomas Hypofractionated radiotherapy Prognosis Insulin-like growth factor 1 Hepatocyte growth factor Correlation

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	SHI Caiyan
	LIU Feng
	LU Hongquan
	et al

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SHI Caiyan,LIU Feng,LU Hongquan, et al. Correlation between Serum IGF-I and HGF Levels and Prognosis of Patients with Hypofractionated Radiotherapy after Gliomas Surgery[J]. HeBei Med, 2021, 27(9): 1477-1481.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.09.016 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I9/1477

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