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| The Expression and Significance of TNF-α IL-6 and VEGF in Serum of Patients with Hypertensive Intracerebral Hemorrhage |
| LIU Siyang, SU Bin, WU Jianlong, et al |
| The Central Hospital of Chengde, Hebei Cheng 067000, China |
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Abstract Objective: To observe and analyze the impact on the prognosis of the serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in patients with hypertensive cerebral hemorrhage (HICH). Methods: 96 HICH patients admitted to Chengde Central Hospital from August 2018 to August 2020 were selected as the observation group, and 30 healthy controls during the same period were selected as the control group. At the same time, the observation group was subgrouped into 2 groups according to the amount of blood loss, 42 cases in the blood loss ≥30mL group, 54 cases in the <30mL group, and also subgrouped into 4 groups according to the prognosis status, 8 cases in the death group, 24 cases in the GCS score 3-8 group, 33 cases in the 9-12 group, 36 cases in GCS13-14 group. Enzyme-linked immunosorbent assay (ELISA) was used to detect serum TNF-α, IL-6 and VEGF levels in HICH patients and healthy subjects, and to analyze the changes in serum TNF-α, IL-6 and VEGF levels in HICH patients among different groups. Results: The levels of serum TNF-α, IL-6 and VEGF in the observation group were significantly higher than those in the control group (P<0.05). The levels of serum TNF-α, IL-6 and VEGF in the blood loss ≥30ml group were significantly higher than those in <30ml group (P<0.05), and the worse the prognosis, the higher the serum TNF-α, IL-6 and VEGF levels, and the changes in TNF-α, IL-6 and VEGF levels among the groups are statistically significant (P<0.05). Conclusion: The levels of TNF-α, IL-6 and VEGF in serum after hypertensive intracerebral hemorrhage may affect the prognosis of patients.
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2021, Vol. 27 
