DcR3 ALB水平与慢阻肺急性加重期合并呼衰患者转归关系

doi:10.3969/j.issn.1006-6233.2021.09.007

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Abstract Objective: To analyze the relationship between the levels of DcR3 and ALB and the prognosis of AECOPD patients with respiratory failure. Methods: From May 2017 to May 2020,93 patients with acute exacerbation of chronic obstructive pulmonary disease in hospital were selected as observation objects, which were divided into observation group (combined respiratory failure ,41 cases) and control group (no symptoms of respiratory failure ,52 cases) according to whether the patients had combined respiratory failure. Differences in serum biochemical and inflammatory factors, arterial blood gas and pulmonary function were observed in the two groups. The survival rate of the two groups was observed at 1 year follow-up, and the independent risk factors affecting the prognosis of AECOPD patients with respiratory failure were analyzed by multivariate analysis. Results: DcR3,CRP,TNF-α in observation group was significantly higher than that in control group(P<0.05). ALB in observation group was significantly lower than that in control group(P<0.05). PO₂ in observation group was significantly lower than that in control group(P<0.05). And the PCO₂ was significantly higher than that in the control group(P<0.05). FEV1%,FEV1/FVC in the observation group were significantly lower than those in the control group(P<0.05). The 1 year survival rate of the patients in the observation group and the control group was 39.0% and 61.54%, and the 1 year survival rate of the patients in the observation group was significantly lower than that in the control group(P<0.05).Through multivariate analysis, DcR3,ALB,CRP,TNF-α,PO₂,PCO₂,FEV1%,FEV1/FVC was found to be an independent risk factor for the prognosis of patients with AECOPD respiratory failure. Conclusion: The expression level of AECOPD patients with respiratory failure increased abnormally compared with AECOPD patients with respiratory failure, while the ALB level showed a downward trend, which was closely related to the patient's disease outcome.

Key words： Chronic obstructive pulmonary disease Respiratory failure Outcome

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.09.007 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I9/1436

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