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| Changes of Serum Total Bile Acids and Hs-CRP BNP Levels in Patients with Atrial Fibrillation and Their Correlation with Heart Rate Variability |
| LI Peng, XU Jianhui, HU Wei |
| Xiaogan Hospital Affiliated to Wuhan University of Science and Technology / Xiaogan Central Hospital,Hubei Xiaogan 432000, China |
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Abstract Objective: To investigate the changes of serum total bile acid (total bile acid,TBA), hypersensitive C reactive protein (hypersensitive C reactive protein,hs-CRP), plasma brain natriuretic peptide (Brain Natriuretic Peptide,BNP) levels and their correlation with heart rate variability (heart rate variability,HRV) in patients with atrial fibrillation. Methods: To select and analyze 217 patients with atrial fibrillation admitted to our department from March 2017 to June 2019, and another 100 healthy controls were selected as control group. Both groups underwent 24 h ECG monitoring. The serum TBA, hs-CRP, BNP levels and the standard deviation (NN standard deviation,) HRV [24h all sinus rhythm intervals], RMSSD were measured and compared. NN standard deviation of mean of interval of mean per 5 mins and PNN50 were recorded. Results: The comparison shows that TBA, hs-CRP, BNP in the study group were higher than in the control group, SDNN, RMSSD, SDANN, PNN50 lower than the control group; the difference was statistically significant (P<0.05). Correlation analysis showed that TBA and SDNN, RMSSD, SDANN, PNN50 are positive (r=0.469,0.474,0.447,0.418, P<0.05); hs-CRP is in positive phase with SDNN, RMSSD, SDANN, PNN50 (r=0.560,0.595,0.600,0.582, P<0.05); BNP and SDNN, RMSSD, SDANN, PNN50 were positive (r=0.566,0.634,0.624,0.598, P<0.05). Conclusion: Serum TBA, hs-CRP, BNP levels increased in patients with atrial fibrillation, and serum TBA, hs-CRP, BNP levels were positively correlated with HRV.
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2021, Vol. 27 
