血清sPD-L1联合Balthazar CT分级对急性胰腺炎患者后期胰周坏死感染的预测能效

doi:10.3969/j.issn.1006-6233.2021.08.020

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Abstract Objective: To investigate the predictive energy efficiency of serum soluble programmed death ligand 1 (sPD-L1) combined with Balthazar CT grading in patients with acute pancreatitis (AP) in the later\ stage of peripancreatic necrosis infection. Methods: 202 cases of AP patients admitted to our hospital from January 2018 to February 2020 were selected and were divided into peripancreatic necrosis and infection group (n = 53) and non peripancreatic necrosis and infection group (n = 149) according to whether there was peripancreatic necrosis and infection after 14 days. General data of the two groups of patients were collected. Multivariate Logistics regression was used to analyze the influencing factors of late peripancreatic necrosis infection in AP patients. The ROC curve was used to analyze the predictive value of sPD-L1 and Balthazar CT grading for the later period of peripancreatic necrosis infection in AP patients. Results: Univariate analysis showed that C-reactive protein (CRP), procalcitonin (PCT), absolute lymphocyte count (ALC), acute physiology and chronic health assessment Ⅱ (APACHE Ⅱ) score, sPD-L1, and Balthazar CT classification were Influencing factors of peripancreatic necrosis infection in AP patients (P<0.05); Multivariate logistic regression analysis showed that APACHE Ⅱ score , sPD-L1 , Balthazar CT grade were independent risk factors for peripancreatic necrosis infection in AP patients (P<0.05); The area under the curve (AUC) of sPD-L1 combined with Balthazar CT classification was 0.878, which was higher than that of sPD-L1 (AUC=0.818), Balthazar CT classification (AUC=0.744) alone(P<0.05). Conclusion: The increase of serum sPD-L1 level and Balthazar CT grading are independent risk factors for later peripancreatic necrosis infection in AP patients. SPD-L1 combined with Balthazar CT grading can improve the predictive value of later peripancreatic necrosis infection in AP patients.

Key words： Acute pancreatitis Peripancreatic necrosis infection Soluble programmed death ligand 1 Balthazar CT classification

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.08.020 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I8/1325

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