急性脑梗死患者血清GLP-1 ICAM-1水平与神经损伤程度的相关性分析

doi:10.3969/j.issn.1006-6233.2021.08.013

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Abstract Objective: To investigate the correlation between the levels of serum glucagon like peptide-1 (GLP-1) and intercellular adhesion factor-1 (ICAM-1) and the degree of nerve injury in patients with acute cerebral infarction (ACI). Methods: A total of 67 patients with ACI in our hospital from October 2018 to December 2019 were selected as the research objects, according to National Institute of Health stroke scale (NIHSS) score, ACI patients were divided into 23 cases in mild group (NIHSS score < 5), 28 cases in moderate group (5 ≤ NIHSS score < 20), and 16 cases in severe group (NIHSS score ≥ 20), and 50 healthy volunteers in our hospital were randomly selected as the control group. The levels of serum GLP-1, ICAM-1, S100 calcium binding protein B (S100B) and neuron specific enolase (NSE) were detected by enzyme-linked immunosorbent assay and compared between the study group and the control group, the serum index levels of each groups were compared. Pearson method was used to analyze the correlation of serum GLP-1, ICAM-1 levels with S100B, NSE levels and NIHSS score. Results: The level of serum GLP-1 in the study group was significantly lower than that in the control group (P<0.05), and the levels of ICAM-1, S100B and NSE in the study group were significantly higher than those in the control group (P<0.05); compared with those in mild group, the level of GLP-1 in moderate group and severe group was significantly lower (P<0.05), and the levels of ICAM-1, S100B and NSE were significantly higher (P<0.05); compared with those in the moderate group, the level of GLP-1 in the severe group was significantly lower (P<0.05), and the levels of ICAM-1, S100B and NSE were significantly higher (P<0.05); compared with before treatment, the level of GLP-1 in ACI patients increased significantly after treatment (P<0.05), the levels of ICAM-1, S100B and NSE and NIHSS score decreased significantly (P<0.05); Pearson results showed that serum GLP-1 level was negatively correlated with ICAM-1, S100B, NSE level and NIHSS score (all P<0.05), and ICAM-1 level was positively correlated with S100B, NSE level and NIHSS score (all P<0.05). Conclusion: With the aggravation of nerve injury in patients with ACI, the level of serum GLP-1 gradually decreases, and the level of ICAM-1 gradually increases, they are closely related to the levels of S100B and NSE, and may be used as potential biological indicators of nerve injury in patients with ACI.

Key words： Acute cerebral infarction Glucagon like peptide-1 Intercellular adhesion molecule-1 Nerve injury

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.08.013 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I8/1294

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