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Predictive Value of Serum Levels of HMGB1, MiR-00-C-3p and CTn Ⅰ on the Prognosis of Neonatal Respiratory Distress Syndrome |
HUO Huiyi, LU Yongxue |
The First People's Hospital of Foshan City, Guangdong Foshan 528000, China |
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Abstract Objective: To explore the predictive value of serum levels of HMGB1, miR-200-c-3p and cTn Ⅰ level on the prognosis of neonatal respiratory distress syndrome. Methods: 120 children with NRDS treated between January 2016 and December 2019 in our hospital were chosen and divided into mild group (n=72, level I and II by X-ray results), severe group (n=48, level III and IV by X-ray results).In addition, 40 normal newborns in our hospital during the same period were selected as the control group. Serum HMGB1, miR-200-c-3p and cTn I level differences were compared between three groups and prognosis was predicted. Results: Serum HMGB1, miR-200c-3p and cTn I levels in the three groups were: severe grouP>mild group>control group (P<0.05).During hospitalization, 34 (28.33%) of 120 patients with NRDS died and 86 (71.67%) survived. There were no significant differences in age, sex, birth weight, maternal age, cesarean section, time of dyspnea, maternal diabetes, maternal hypertension, meconium inhalation, intrauterine distress, neonatal asphyxia, etc. between the two groups (P>0.05), but the differences in disease, HMGB1, miR-200c-3p and cTn I between the two groups were statistically significant (P<0.05). ROC curve analysis showed that the AUC of HMGB1, miR-200c-3p and CTN I in NRDS patients were 0.933, 0.892 and 0.766, with high accuracy. Taking the maximum tangent point of Youden index at the upper left of ROC curve as the optimal critical value, the sensitivity and specificity of HMGB1, miR-200c-3p and CTN I were 91.2%, 82.4%, 50.0% and 91.9%, 100.0% , 100.0% at this point, indicating a high predictive value. The AUC of the three combined predictions was 0.925, and the sensitivity and specificity were 85.3% and 98.8%, indicating high predictive value. Conclusion: Serum HMGB1, miR-200-c-3p and cTn I levels in children with NRDS has high expression, and is closely related to the degree of disease with high value of prognostic assessment.
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[1] Debisschop B,Derriks F,Cools F.Early predictors for intubation-SURfactant-extubation failure in preterm infants with neonatal respiratory distress syndrome: a systematic review[J].Neonatology,2019,117(1):1~13. [2] 冯爱民,谢秀春,王苗,等.肺表面活性物质联合无创高频振荡通气治疗新生儿呼吸窘迫综合征的效果观察[J].河北医学,2019,25(3):551~555. [3] Elkabany Z A,El-Farrash R A,Shinkar D M,et al.Oxidative stress markers in neonatal respiratory distress syndrome: advanced oxidation protein products and 8-hydroxy-2-deoxyguanosine in relation to disease severity[J].Pediatric Research,2019,87(1):1. [4] 吴婷婷,贺巧峰,曹玲.N末端脑钠肽前体与心肌肌钙蛋白Ⅰ评价新生儿呼吸窘迫综合征预后的临床价值[J].中国儿童保健杂志,2019,27;209(11):69~73. [5] 涂菊,彭海燕.血清HMGB1水平对早产儿呼吸窘迫综合征病情评估的价值[J].检验医学,2019,34(7):617~621. [6] 章伟,陈波,张惠荣,等.SNAPPE-Ⅱ评分对新生儿呼吸窘迫综合征预后的预测价值[J].广东医学,2017,38(20):3153~3154. [7] 李宏宾,訾盼盼,石慧娟,等.长链非编码RNA生长阻滞特异转录物5/微小RNA 200c-3p/血管紧张素转换酶2信号轴参与呼吸窘迫综合征人肺上皮细胞A549的凋亡[J].中华医学杂志,2018,98(41):3354. [8] 古裕鸟,霍开明,庄秀娟,等.血清miR-200c-3p表达水平对判断新生儿呼吸窘迫综合征严重程度和预后的价值[J].临床儿科杂志,2020,038(4):250~254. [9] 陈小冰,张雪梅,陈求凝,等.血清miR-34a及miR-155在新生儿急性呼吸窘迫综合征中的表达及临床意义[J].中国急救医学,2020,40(4):334~338. [10] 王文秀,陈波,章伟,等.血清高迁移率族蛋白B1与新生儿呼吸窘迫综合征的相关性研究[J].中国当代儿科杂志,2017,19(4):398~401. |
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