腹腔镜胃癌根治术对胃癌患者能量代谢外周血T细胞亚群和患者肠屏障功能机体炎性应激水平和免疫功能的影响

doi:10.3969/j.issn.1006-6233.2021.07.028

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Abstract Objective: To explore the effects of laparoscopic radical gastrectomy on energy metabolism, peripheral blood T cell subsets, intestinal barrier function, body’ s inflammatory stress level and immune function in patients with gastric cancer. Methods: A total of 142 patients with gastric cancer admitted to our hospital from June 2017 to June 2020 were selected as the research subjects. According to the surgical methods, 142 patients were divided into laparoscopic surgery group (observation group, n=75) and open surgery group (control group, n=67). The energy metabolism [albumin (ALB), prealbumin (PA), retinol binding protein (RBP), transferrin (TRF)], intestinal barrier function [diamine oxidase (DAO), D-lactic acid], inflammatory stress level [C reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)], peripheral blood T cell subsets (CD4⁺, CD8⁺, CD4⁺/CD8⁺) and immunoglobulins (IgA, IgG, IgM) were compared between the two before and after surgery. Results: At 3 days after surgery, the levels of serum ALB, PA, RBP, TRF, TNF-α, IgA, IgG and IgM and peripheral blood CD4⁺ and CD4⁺/CD8⁺in the two groups were decreased compared with those before surgery(P<0.05). At 3d after surgery, the levels of plasma DAO and D-lactic acid and serum CRP in the two groups were increased compared with those before surgery (P<0.05). At 1 day after surgery, the level of serum IL-6 in the two groups was higher than that before surgery (P<0.05). The changes of above indexes before and after surgery in observation group were lower than those in control group (P<0.05). Conclusion: Compared with open surgery, laparoscopic radical gastrectomy has less effect on energy metabolism, intestinal barrier function, inflammatory stress level and immune function, and it is beneficial to postoperative recovery.

Key words： Laparoscopy Radical gastrectomy Energy metabolism Intestinal barrier function Inflammatory stress response Immune function

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.07.028 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I7/1186

[1] 哈丽达·夏尔甫哈孜,冯娟,范晓棠,等.进展期胃癌根治术后5年预后因素分析及生存预测模型的建立[J].胃肠病学和肝病学杂志,2020,29(10):1129~1133.
[2] 刘珞,危志远,傅志雄,等.完全腹腔镜与开腹远端胃癌根治术治疗进展期胃癌的疗效对比分析[J].腹腔镜外科杂志,2020,25(9):683~687.
[3] 王政强,王春.腹腔镜胃癌根治术与开腹胃癌根治术治疗胃癌疗效比较[J].新乡医学院学报,2020,37(4):386~390.
[4] 张伟,蔡振花,周瑞轻,等.腹腔镜胃癌根治术在早期胃癌的近期临床疗效和应激因子的研究[J].中华普外科手术学杂志(电子版),2020,14(4):411~413.
[5] 陈孝平,汪建平.外科学[M].第8版.北京:人民卫生出版社,2013.213.
[6] 李阳.腹腔镜胃癌根治术后并发症观察及对应激反应的影响[J].中国现代普通外科进展,2020,23(9):716~718.
[7] 魏雪莲.腹腔镜辅助胃癌根治术对胃癌肠道屏障功能、血清炎性因子水平影响及护理对策分析[J].基因组学与应用生物学,2018,37(10):4595~4601.
[8] 刘慧琳,张丹,邓祥竹,等.血清白蛋白、前白蛋白、视黄醇结合蛋白及转铁蛋白在胃癌术后肠外营养支持中的意义[J].中国医药导报,2018,15(5):113~116.
[9] 田庆林,李阳,陈晓峰.腹腔镜远端胃癌根治术毕Ⅱ式联合Braun吻合术对胃癌肠道屏障功能血清炎性因子水平的影响[J].河北医学,2020,26(1):41~45.
[10] 李华,郭丽,憨镔,等.参苓白术散化裁对胃癌术后化疗患者肠道菌群、肠屏障和免疫功能的调节作用分析[J].肿瘤药学,2020,10(4):477~482.
[11] 曹玉华,陈玉旋,李丹.快速康复外科干预对老年患者腹腔镜胃癌根治术后应激反应、细胞免疫功能和生活质量的影响[J].中国医学前沿杂志(电子版),2020,12(1):137~140.
[12] 王晓明,孙贺,孟刚,等.腹腔镜辅助胃癌根治术和常规开腹胃癌根治术对患者免疫指标及微转移的影响[J].癌症进展,2019,17(3):311~314.